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Alzheimer's disease & dementia news

Medical research

Dietary compound increases longevity and protects against Alzheimer's disease in experimental models

Researchers from the Color and Food Quality group at the Faculty of Pharmacy (University of Seville), in collaboration with Dr. Marina Ezcurra's group at the University of Kent (U.K.), have shown that the carotenoid phytoene ...

Alzheimer's disease & dementia

Questions over safety and effectiveness of new Alzheimer's drug

The safety and effectiveness of donanemab—an Alzheimer's drug recently approved by the US Food & Drug Administration (FDA)—is called into question in an investigation published by The BMJ.

Genetics

Master copper regulator discovery may offer Alzheimer's clues

New therapeutic opportunities often emerge from research on simple organisms. For instance, the 2020 Nobel Prize in Chemistry awarded to Emmanuelle Charpentier, Ph.D., and Jennifer Doudna, Ph.D., for their CRISPR-based DNA ...

Alzheimer's disease & dementia

Boosting brain protein levels may slow decline from Alzheimer's

A study published in the journal Brain shows that increases in protein levels with new Alzheimer's drugs can explain the slowing of cognitive impairment at least as well as the reduction in amyloid plaques.

Alzheimer's disease & dementia

Human neuron model paves the way for new Alzheimer's therapies

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease ...

Neuroscience

Untangling the threads of early onset dementia

Changes in personality, behavior and language are hallmarks of frontotemporal dementia (FTD), the most common form of dementia in patients under the age of 65, which is associated with degeneration of the frontal and temporal ...

Alzheimer's disease & dementia

Immunotherapy for Alzheimer's disease shows promise in mouse study

Alzheimer's disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer's ...

Neuroscience

New imaging method illuminates oxygen's journey in the brain

The human brain consumes vast amounts of energy, which is almost exclusively generated from a form of metabolism that requires oxygen. While the efficient and timely delivery of oxygen is known to be critical to healthy brain ...

Alzheimer's disease & dementia

Unlocking how to use mRNA to target Alzheimer's disease

Scientists at The Florey have developed an mRNA technology approach to target the toxic protein tau, which builds up in patients with Alzheimer's disease and other dementias.

Alzheimer's disease & dementia

Patients with delirium more likely to develop dementia, finds study

University of Queensland researchers have found older patients who experience delirium are three times more likely to develop dementia. Professor Ruth Hubbard from UQ's Center for Health Services Research (CHSR) said the ...

Neuroscience

Understanding the role of microglia in Alzheimer's disease

Microglia are specialized immune cells in the brain. While they normally protect our brains, they can also contribute to neurodegenerative diseases such as Alzheimer's. The exact mechanism behind this contribution is not ...