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Arthritis & Rheumatism

Study offers potential for early diagnosis and therapeutic intervention for rheumatoid arthritis

Currently, there are no cures for rheumatoid arthritis (RA), which affects 40,000 people in Ireland. The disease costs an estimated $22,000 per patient, per year with an overall cost to the health system of ~$608 million. ...

Arthritis & Rheumatism

AI chatbots rival doctors in accuracy for back pain advice, study finds

A new study reveals that artificial intelligence chatbots, such as ChatGPT, may be almost as effective as consulting a doctor for advice on low back pain.

Arthritis & Rheumatism

Study shows AFL players' hip issues begin in early career

Researchers from La Trobe University studied 58 pain-free male Australian Football League (AFL) draftees, finding that nearly half showed hip joint changes on Magnetic Resonance Imaging (MRI) and 20% had a particular hip ...

Arthritis & Rheumatism

Study uncovers key factors in myositis-induced muscle weakness

A study has shed new light on the mechanisms behind idiopathic inflammatory myopathies (myositis), a group of systemic autoimmune disorders known for causing severe muscle weakness, fatigue, and increased mortality.

Arthritis & Rheumatism

Machine learning helps identify rheumatoid arthritis subtypes

A machine-learning tool created by Weill Cornell Medicine and Hospital for Special Surgery (HSS) investigators can help distinguish subtypes of rheumatoid arthritis (RA), which may help scientists find ways to improve care ...

Arthritis & Rheumatism

Surprising mechanism of lupus kidney damage identified

A Berlin-led research team has uncovered critical regulators of severe kidney damage in patients with lupus, an autoimmune disorder affecting an estimated five million people worldwide, most of whom are young women. A small, ...

Arthritis & Rheumatism

How mitochondrial damage ignites the 'auto-inflammatory fire'

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and ...

Arthritis & Rheumatism

Patients with lupus benefit from COVID-19 vaccine booster

People with systemic lupus erythematosus (SLE) who received a "booster" dose of SARS-CoV-2 vaccine after full vaccination are roughly half as likely to have a subsequent "breakthrough" COVID-19 infection, a new study shows.

Arthritis & Rheumatism

Discovery of molecular pathway through which stress affects lupus

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects all the organ systems of the body. This chronic disease includes periods of illness, called flare ups, and periods of remission, when symptoms are few. ...

Arthritis & Rheumatism

Should clinicians reconsider standard therapy for gout?

Gout occurs when urate crystals accumulate in the joints, and xanthine oxidase inhibitors such as febuxostat are a mainstay of therapy to help reduce blood urate levels in affected patients. A recent clinical trial published ...

Arthritis & Rheumatism

Study lays foundation for new psoriasis treatment strategy

About 250,000 people in Austria suffer from psoriasis. One third of them develop inflammation in their joints (psoriatic arthritis) as a result of the chronic skin condition. As part of a study, a MedUni Vienna research team ...

Arthritis & Rheumatism

Most common allergies not linked to rheumatoid arthritis

Most common allergies are not associated with the risk for rheumatoid arthritis (RA), but some allergic conditions, including animal dander allergy and atopic dermatitis, are associated with increased RA risk, according to ...

Arthritis & Rheumatism

Obesity lowering the age for knee replacements

More than half of Australians who underwent knee replacement for osteoarthritis were obese, increasing their risk of having the operation at a younger age, especially among women.

Medical research

UHRF1 suppresses pathogeneses in rheumatoid arthritis

Rheumatoid arthritis (RA) is characterized by chronic inflammation of synovium, eventually leading to joint destruction. Epigenetic alteration (the mechanism of gene expression regulation without DNA sequence changes), such ...

Arthritis & Rheumatism

The importance of treatment goals in PSA

PsA is a type of inflammatory arthritis linked to psoriasis—a chronic condition affecting the skin and nails. People with PsA experience pain and swelling in their joints, and at the points where tendons and ligaments attach ...

Arthritis & Rheumatism

Patient involvement and empowerment: Coping with rheumatic diseases

At the 2022 EULAR Congress, Joana Vicente presented the findings of a survey which set out to identify the levels of invalidation and lack of understanding felt by adults with RMDs from health professionals and other people. ...

Arthritis & Rheumatism

Investigating the link between a type of antibody and miscarriage

Miscarriage affects an estimated 15% of pregnancies, but in about half of cases the cause is unclear. At Yale, reproductive immunologist Vikki Abrahams and reproductive biologist Mancy Tong are interested in shining a light ...