Diseases, Conditions, Syndromes

New guidelines for hepatic failure in the intensive care unit

For critical care specialists, hepatic failure poses complex challenges unlike those of other critical illnesses. A new set of evidence-based recommendations for management of liver failure is presented in the March issue ...

Diseases, Conditions, Syndromes

China reports first death from mystery pneumonia outbreak

A 61-year-old man has become the first person to die in China from a respiratory illness believed caused by a new virus from the same family as SARS, which claimed hundreds of lives more than a decade ago, authorities said.

Genetics

Cause of acute liver failure in young children discovered

Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent of cases it is unclear as to why this happens. ...

Diseases, Conditions, Syndromes

Researchers develop new approach to treat acute liver failure

Acute liver failure is a life-threatening disease, characterized by a sudden, massive death of liver cells. Unfortunately, few treatment options exist, especially for advanced-stage liver failure. As a last resort a liver ...

Diseases, Conditions, Syndromes

Cellular target may aid in drug therapies for acute liver failure

(Medical Xpress) -- New insights into the biological mechanisms that contribute to acute liver failure could help scientists better understand—and eventually treat—a broader spectrum of liver diseases, according ...

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Acute liver failure is the appearance of severe complications rapidly after the first signs of liver disease (such as jaundice), and indicates that the liver has sustained severe damage (loss of function of 80-90% of liver cells). The complications are hepatic encephalopathy and impaired protein synthesis (as measured by the levels of serum albumin and the prothrombin time in the blood). The 1993 classification defines hyperacute as within 1 week, acute as 8–28 days and subacute as 4–12 weeks. It reflects the fact that the pace of disease evolution strongly influences prognosis. Underlying etiology is the other significant determinant of outcome.

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