Diseases, Conditions, Syndromes

Favorable outcomes seen in long term for ALLR3 trial

(HealthDay)—For children with B-cell precursor acute lymphoblastic leukemia with late bone marrow relapse, risk stratification by minimal residual disease seems to be an effective strategy for treatment, according to a ...

Cancer

Understanding the emergence of leukemia

Acute T-cell lymphoblastic leukemia is a rare type of blood cancer that affects mostly children. This blood cancer appears from the precursor cells that produce T lymphocytes (a type of white blood cells). A new study from ...

Cancer

Obesity linked to adverse events in children with leukemia

(HealthDay)—For children with acute lymphoblastic leukemia (ALL), obesity is associated with an increased risk for adverse events during premaintenance chemotherapy, according to a study published in the February issue ...

Cancer

Molecular mechanisms behind AICAr drug; impact on ALL

AICAr (5-amino-4-imidazolecarboxamide riboside, also called Acadesine) has been found to inhibit cell proliferation and has cytotoxic potential for childhood acute lymphoblastic leukemia (ALL) cells. Much of the drug's cytotoxic ...

Cancer

Researchers characterize mechanism of action of CAR T cells

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells. ...

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Acute lymphoblastic leukemia (ALL) is a form of leukemia, or cancer of the white blood cells characterized by excess lymphoblasts.

Malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. ALL causes damage and death by crowding out normal cells in the bone marrow, and by spreading (infiltrating) to other organs. ALL is most common in childhood with a peak incidence at 2–5 years of age, and another peak in old age. The overall cure rate in children is about 80%, and about 45%-60% of adults have long-term disease-free survival.

Acute refers to the relatively short time course of the disease (being fatal in as little as a few weeks if left untreated) to differentiate it from the very different disease of chronic lymphocytic leukemia, which has a potential time course of many years. It is interchangeably referred to as Lymphocytic or Lymphoblastic. This refers to the cells that are involved, which if they were normal would be referred to as lymphocytes but are seen in this disease in a relatively immature (also termed 'blast') state.

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