T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that arises from the malignant transformation of T-cell progenitors. This disease is most commonly diagnosed in children, where it accounts for ...
Jul 23, 2024
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The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, ...
Jul 22, 2024
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CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy ...
Jul 10, 2024
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As climate change warms the planet, high ambient temperatures are expected to be more common and intense over the coming decades in the U.S. and worldwide.
Jul 4, 2024
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Researchers show for the first time that engineered human plasma B cells can be used to treat a disease—specifically leukemia—in a humanized animal model. The results mark a key step in the realization of ePCs as therapies ...
Jul 2, 2024
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Understanding the molecular characteristics of cancer that impact patient outcomes is essential to identifying novel treatment strategies for the most intractable pediatric malignancies. Many of these diseases are difficult ...
Jun 26, 2024
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While most cell types experience a functional decline after years of proliferation and replication, T cells can proliferate seemingly indefinitely and without detriment.
Jun 12, 2024
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Valrubicin, a lipophilic chemical molecule similar to daunorubicin, has primarily been used in the treatment of bladder cancer. An article recently published in Cell Death & Disease describes the repurposing of this molecule ...
Jun 6, 2024
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Researchers from Karolinska Institutet have, in collaboration with the University of Eastern Finland and Lund University, published a study in Genome Biology demonstrating that targeting cell cycle and cell fate regulatory ...
Jun 3, 2024
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Researchers from The University of Texas MD Anderson Cancer Center presented positive clinical results from two studies today at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.
May 31, 2024
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