Cardiology

A better way to classify young women's heart attacks

Women age 55 and younger are less likely to exhibit the classic symptoms and underlying mechanisms of a heart attack commonly observed in men. This can leave women undiagnosed and at great risk.

Medications

New targets for ischemic drugs

Russian scientists investigated the role of opioid receptors in protecting the heart from coronary disease: the lack of its blood supply. These receptors are mainly responsible for pain regulation. It turned out that they ...

Cardiology

Outcomes for AMI improved during 1995 to 2014

(HealthDay)—Short-term mortality and readmissions improved from 1995 to 2014 for patients with acute myocardial infarction (AMI), according to a study published online March 15 in JAMA Network Open.

Cardiology

Best practices developed for diagnosing, managing MINOCA

(HealthDay)—In an American Heart Association scientific statement published online March 27 in Circulation, best practices are presented for diagnostic evaluation and management of myocardial infarction in the absence of ...

Medical research

Researchers create a new molecule to treat heart failure

A group of researchers based in Brazil and the United States have developed a molecule that halts the progression of heart failure and improves the heart's capacity to pump blood. Rats with heart failure were treated for ...

Health

Late dinner and no breakfast is a killer combination

People who skip breakfast and eat dinner near bedtime have worse outcomes after a heart attack. That's the finding of research published today in the European Journal of Preventive Cardiology, a journal of the European Society ...

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Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms.

Among the diagnostic tests available to detect heart muscle damage are an electrocardiogram (ECG), echocardiography, cardiac MRI and various blood tests. The most often used blood markers are the creatine kinase-MB (CK-MB) fraction and the troponin levels. Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual nitroglycerin.

Most cases of STEMI (ST elevation MI) are treated with thrombolysis or percutaneous coronary intervention (PCI). NSTEMI (non-ST elevation MI) should be managed with medication, although PCI is often performed during hospital admission. In people who have multiple blockages and who are relatively stable, or in a few emergency cases, bypass surgery may be an option, especially in diabetics.

Heart attacks are the leading cause of death for both men and women worldwide. Important risk factors are previous cardiovascular disease, older age, tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein) and low levels of high density lipoprotein (HDL), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

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