Medical research

New treatment for African sleeping sickness comes closer

Researchers at Umeå University have identified drugs targeting infections of the parasite Trypanosoma brucei and are thereby well on the way to find a cure against African sleeping sickness. This is the kernel of a thesis, ...

Diseases, Conditions, Syndromes

Gene clue to drug resistance in African sleeping sickness

(Medical Xpress) -- Researchers have identified a gene that controls susceptibility to drug treatment in Trypanosoma brucei, the parasite responsible for African sleeping sickness.

Diseases, Conditions, Syndromes

New diagnostic test for human African Sleeping Sickness

A new diagnostic test developed from research at the Universities of Dundee and Cambridge has been launched with the aim of helping eliminate the disease known as African sleeping sickness.

Diseases, Conditions, Syndromes

African sleeping sickness: a tale of two parasites

(Medical Xpress) -- The savannahs and rainforests of Africa bring to mind romantic notions of wildlife, adventure and exploration. But beneath this natural beauty lies a deadly, long-neglected disease: trypanosomiasis, otherwise ...

Medications

New oral drug candidate for African sleeping sickness

A new oral-only treatment for sleeping sickness has entered Phase II/III clinical study in patients with late-stage sleeping sickness in the Democratic Republic of the Congo (DRC) and soon in Central African Republic (CAR). ...

Diseases, Conditions, Syndromes

Fly gut bacteria could control sleeping sickness

A new bacterial species, found in the gut of the fly that transmits African sleeping sickness, could be engineered to kill the parasite that causes the disease. The study, published in the International Journal of Systematic ...

Immunology

Sleeping sickness by stealth

(Medical Xpress)—Stealth is a well-known concept in military tactics. Almost since the invention of radar, the hunt began for counter-technologies to hide aircraft and missiles from detection – most successfully by modifying ...

Medical research

Sleeping sickness treatment mystery unlocked

(Medical Xpress)—Scientists at the Universities of Dundee and Glasgow have discovered how drugs that have been used for 60 years to kill the parasite that causes sleeping sickness actually work.

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Human African trypanosomiasis, sleeping sickness, African lethargy, or Congo trypanosomiasis is a parasitic disease of people and animals, caused by protozoa of the species Trypanosoma brucei and transmitted by the tsetse fly. The disease is endemic in some regions of sub-Saharan Africa, covering about 37 countries and 60 million people. It is estimated that 50,000 to 70,000 people are currently infected, the number having declined somewhat in recent years. The number of reported cases was below 10,000 in 2009, the first time in 50 years. It is believed that many cases go unreported. About 48,000 people died of it in 2008. Four major epidemics have occurred in recent history: one from 1896–1906 primarily in Uganda and the Congo Basin, two epidemics in 1920 and 1970 in several African countries, and a recent 2008 epidemic in Uganda.

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