Diseases, Conditions, Syndromes

Serum free light chain level increase precedes amyloidosis

(HealthDay)—Increased serum free light chains (FLCs) precede the presentation of immunoglobulin light chain amyloidosis (AL amyloidosis), according to a study published online July 14 in the Journal of Clinical Oncology.

Cardiology

Three-drug tx ups survival in light-chain amyloidosis

(HealthDay)—For patients with heart failure due to light-chain amyloidosis (AL), three-drug therapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved survival, according to a ...

Medical research

Researcher determines link between foie gras and diseases

University of Tennessee Graduate School of Medicine professor and researcher Alan Solomon, M.D., director of the Human Immunology and Cancer/Alzheimer’s Disease and Amyloid-Related Disorders Research Program, led a team ...

Diseases, Conditions, Syndromes

Patient-reported symptom score predicts outcome in amyloidosis

(HealthDay)—A patient-reported symptom score can help predict clinical outcomes in patients with light-chain amyloidosis (AL), according to a study published online Feb. 9 in the American Journal of Hematology.

Cardiology

Amyloid scan of the heart predicts major cardiac events

Amyloid build-up is commonly talked about in relation to Alzheimer's disease, but amyloidosis can be found throughout the body. An excessive accumulation of these insoluble proteins could cause a heart attack or even death. ...

Alzheimer's disease & dementia

Amyloid study pinpoints protein culprits

A five-year trial at a Brisbane Hospital has increased the accuracy of diagnosing patients with amyloidosis, a group of rare and incurable diseases caused by abnormal protein deposits in tissues and organs.

Neuroscience

Study examines memory and effects on the aging brain

A study of brain aging finds that being male was associated with worse memory and lower hippocampal volume in individuals who were cognitively normal at baseline, while the gene APOE ?4, a risk factor for Alzheimer disease, ...

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Amyloid Light-chain (AL) amyloidosis, primary systemic amyloidosis (PSA) or just primary amyloidosis is the most common form of systemic amyloidosis in the US. The disease is caused when a person's antibody-producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains. These light chains come together to form amyloid deposits in different organs which can cause serious damage to these organs. Abnormal light chains in blood and urine are sometimes referred to as "M-protein" or "Bence Jones protein".

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