Oncology & Cancer

Powerful myeloma treatment regimen shows promise for AL amyloidosis

Two studies published today in Blood, the Journal of the American Society of Hematology (ASH), demonstrate preliminary success of an effective multiple myeloma (MM) regimen in patients with AL amyloidosis, a rare and devastating ...

Diseases, Conditions, Syndromes

Serum free light chain level increase precedes amyloidosis

(HealthDay)—Increased serum free light chains (FLCs) precede the presentation of immunoglobulin light chain amyloidosis (AL amyloidosis), according to a study published online July 14 in the Journal of Clinical Oncology.

Cardiology

Three-drug tx ups survival in light-chain amyloidosis

(HealthDay)—For patients with heart failure due to light-chain amyloidosis (AL), three-drug therapy with bortezomib, dexamethasone, and an alkylating agent (BDex+AA) is associated with improved survival, according to a ...

Alzheimer's disease & dementia

New sensitive method for early detection of amyloidosis in humans

A team of scientists at Sweden's Linköping University has developed a molecular probe that can detect an array of different amyloid deposits in several human tissues. This new probe is extremely sensitive and was used at ...

Cardiology

PET imaging visualizes hard-to-diagnose cardiac amyloidosis

Researchers at Princess Alexandra Hospital, Brisbane, Australia, have demonstrated that cardiac amyloidosis (abnormal deposits of proteins in the heart), which is notoriously difficult to diagnose, can be visualized noninvasively ...

Cardiology

Amyloid scan of the heart predicts major cardiac events

Amyloid build-up is commonly talked about in relation to Alzheimer's disease, but amyloidosis can be found throughout the body. An excessive accumulation of these insoluble proteins could cause a heart attack or even death. ...

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Amyloid Light-chain (AL) amyloidosis, primary systemic amyloidosis (PSA) or just primary amyloidosis is the most common form of systemic amyloidosis in the US. The disease is caused when a person's antibody-producing cells do not function properly and produce abnormal protein fibers made of components of antibodies called light chains. These light chains come together to form amyloid deposits in different organs which can cause serious damage to these organs. Abnormal light chains in blood and urine are sometimes referred to as "M-protein" or "Bence Jones protein".

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