Amyotrophic lateral sclerosis (ALS) is an intractable disease of the motor neurons for which there is currently no radical cure. ALS causes reductions in patient ability to walk, any many patients required invasive or non-invasive ...
Sep 18, 2023
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Researchers at The Ohio State University Wexner Medical Center and College of Medicine have led the creation of evidence-based consensus guidelines for genetic testing and counseling for patients with amyotrophic lateral ...
Sep 14, 2023
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The human microbiome includes the genetic material of more than 100 trillion tiny microorganisms—fungi, yeast, bacteria, and even viruses, most of which hang out in our gastrointestinal tract to serve as guardians of our ...
Sep 13, 2023
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Researchers have developed an engineered adeno-associated virus (AAV) vector that yields high transduction of brain vascular pericytes and smooth muscle cells. The study describing the characterization of this novel AAV capsid ...
Aug 24, 2023
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Pat Bennett's prescription is a bit more complicated than "Take a couple of aspirins and call me in the morning." But a quartet of baby-aspirin-sized sensors implanted in her brain are aimed at addressing a condition that's ...
Aug 23, 2023
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Brain implants have long been trapped in the realm of science fiction, but a steady trickle of medical trials suggests the tiny devices could play a big part in humanity's future.
Aug 20, 2023
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Our movements are controlled by multiple neural pathways that connect the brain and spinal cord. In particular, neurons in the cerebral cortex send commands to the motor neurons in the spinal cord and then to the muscles, ...
Aug 18, 2023
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Recent neuroscience studies have consistently outlined the role of the C9ORF72 gene in the development of some neurodegenerative diseases. These studies found that mutations of this gene increase the risk of developing amyotrophic ...
Researchers at the Francis Crick Institute and UCL have shown that hundreds of proteins and mRNA molecules are found in the wrong place in nerve cells affected by motor neuron disease (MND), also known as amyotrophic lateral ...
Jul 21, 2023
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New research appearing in the journal Nature Biotechnology answers important questions about the viability of treatments that seek to replace diseased and aged cells in the central nervous system with healthy ones. Its findings ...
Jul 17, 2023
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Amyotrophic lateral sclerosis (ALS), also referred to as Lou Gehrig's disease in American English and Motor Neurone Disease in British English, is a form of Motor Neuron Disease caused by the degeneration of upper and lower neurons, located in the ventral horn of the spinal cord and the cortical neurons that provide their efferent input. The condition is often called Lou Gehrig's disease in North America, after the New York Yankees baseball player who was diagnosed with the disease in 1939. The disorder is characterized by rapidly progressive weakness, muscle atrophy and fasciculations, spasticity, dysarthria, dysphagia, and respiratory compromise. Sensory function generally is spared, as is autonomic and oculomotor activity. ALS is a progressive, fatal, neurodegenerative disease with most affected patients dying of respiratory compromise and pneumonia after 2 to 3 years; although some perish within a year from the onset of symptoms, and occasional individuals have a more indolent course and survive for many years.
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