Health

Patients seeking assisted dying confront a range of barriers

One in every five Americans now lives in a state with legal access to a medically assisted death. In theory, assisted dying laws allow patients with a terminal prognosis to hasten the end of their life, once their suffering ...

Psychology & Psychiatry

Neurological disorders are linked to elevated suicide rates

A newly published study in JAMA shows that people with neurological disorders have a 75% higher suicide rate than people with no neurological disorders. Still, suicide deaths are rare events. While the suicide rate for the ...

Neuroscience

Brain inflammation in veterans with Gulf War illness

In a new discovery, researchers at Massachusetts General Hospital (MGH) have detected widespread inflammation in the brains of veterans diagnosed with Gulf War Illness (GWI). These findings, published online in the journal ...

Genetics

Gene therapy can protect against ALS and SMA-related cell death

Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene ...

Neuroscience

Pedal to the metal: Speeding up treatments for ALS

A therapeutic intervention for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, could be on the horizon thanks to unexpected findings by University of Arizona researchers.

Neuroscience

Immunity key to motor neurone disease treatment

Customized immune-blocking medication may be the key to treating patients with motor neurone disease (MND), which currently has no cure and limited therapeutic options.

Genetics

Scientists discover link between ALS genes

The enzyme Gemin3 was identified as the molecular 'bridge' between genes whose mutation or disruption causes amyotrophic lateral sclerosis (ALS), according to a new study in Nature's Scientific Reports from scientists at ...

Medical research

A common insulin signaling pathway across cancer and diabetes

An oncology researcher has made an unexpected contribution to the understanding of type 2 diabetes. In results published in Science Advances, Patrick Hu, M.D., associate professor of medicine at Vanderbilt University Medical ...

Diseases, Conditions, Syndromes

New clues to the link between ALS and type 2 diabetes

Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular ...

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Amyotrophic lateral sclerosis (ALS), also referred to as Lou Gehrig's disease in American English and Motor Neurone Disease in British English, is a form of Motor Neuron Disease caused by the degeneration of upper and lower neurons, located in the ventral horn of the spinal cord and the cortical neurons that provide their efferent input. The condition is often called Lou Gehrig's disease in North America, after the New York Yankees baseball player who was diagnosed with the disease in 1939. The disorder is characterized by rapidly progressive weakness, muscle atrophy and fasciculations, spasticity, dysarthria, dysphagia, and respiratory compromise. Sensory function generally is spared, as is autonomic and oculomotor activity. ALS is a progressive, fatal, neurodegenerative disease with most affected patients dying of respiratory compromise and pneumonia after 2 to 3 years; although some perish within a year from the onset of symptoms, and occasional individuals have a more indolent course and survive for many years.

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