Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), also referred to as Lou Gehrig's disease in American English and Motor Neurone Disease in British English, is a form of Motor Neuron Disease caused by the degeneration of upper and lower neurons, located in the ventral horn of the spinal cord and the cortical neurons that provide their efferent input. The condition is often called Lou Gehrig's disease in North America, after the New York Yankees baseball player who was diagnosed with the disease in 1939. The disorder is characterized by rapidly progressive weakness, muscle atrophy and fasciculations, spasticity, dysarthria, dysphagia, and respiratory compromise. Sensory function generally is spared, as is autonomic and oculomotor activity. ALS is a progressive, fatal, neurodegenerative disease with most affected patients dying of respiratory compromise and pneumonia after 2 to 3 years; although some perish within a year from the onset of symptoms, and occasional individuals have a more indolent course and survive for many years.

This text uses material from Wikipedia licensed under CC BY-SA

Latest Spotlight News

Can coffee perk up heart health, too?

The caffeine in your morning cup of joe may do more than jolt you awake—it may also help dampen the type of inflammation that's linked to heart disease risk factors, a new study suggests.

Protein may protect tumor-initiating breast cancer cells

Massachusetts General Hospital investigators have identified a protein that may play an essential role in maintaining a population of tumor-initiating cells (TICs)—treatment-resistant cells responsible for cancer recurrence ...

Metabolic sensor causes granulomas to form

Granulomas are tissue nodules of immune cells that occur in diseases such as tuberculosis and sarcoidosis and can damage many organs. For the first time, a team of researchers at the Center for Pathobiochemistry and Genetics ...