The RB1 tumor suppressor gene protein antagonizes uncontrolled growth of cancer by suppressing cell cycle progression but its function is repressed in most cancers. CDK4/6 represses this function by phosphorylating RB1. In ...
Sep 2, 2021
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Clear cell renal cell carcinoma (ccRCC) cells can be destroyed and kept from multiplying by inhibiting the HDL cholesterol receptor SCARB1, according to research from the Perelman School of Medicine at the University of Pennsylvania. ...
Aug 11, 2021
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New results from researchers at Queen Mary University of London confirm the role of Human Epidermal Growth Factor Receptor (HER2) in predicting long-term outcomes for Ductal Carcinoma In Situ (DCIS), a pre-invasive stage ...
Aug 11, 2021
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Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma, according to results from a phase II clinical trial published in ...
Aug 6, 2021
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Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, ...
Aug 5, 2021
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Keratinocyte carcinomas, including basal cell and squamous cell carcinomas, are the most common types of cancer in the United States, with approximately 5.4 million cases diagnosed each year. Despite their low mortality rate, ...
Aug 3, 2021
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A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.
Jul 29, 2021
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A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration ...
Jul 23, 2021
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Immunotherapy has revolutionized the treatment of inoperable, metastasised skin cancer. More than 50% of patients are still alive more than five years after treatment, whereas, 10 years ago, this figure was not even 5%. The ...
Jul 20, 2021
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A research group led by Prof. Piao Hailong from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) identified hepatocellular carcinoma (HCC) subtypes with distinctive metabolic phenotypes ...
Jul 12, 2021
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