We all know that a strong immune system is a definite advantage. Yet, sometimes, the immune system goes awry and attacks the body. This autoimmunity is the cause of various disorders, such as rheumatoid arthritis, Crohn's ...
Apr 5, 2023
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(HealthDay)—An experimental drug may quickly quash symptoms of the digestive disorder Crohn's disease—at least for the short term, an early clinical trial finds.
Mar 19, 2015
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A new type of vaccine developed by researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis, ...
Sep 11, 2023
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Though oral health issues can affect overall health, the two are considered unrelated and are frequently addressed separately when it comes to treatment. However, existing research shows that patients with inflammatory bowel ...
The Centre for Digestive Disease (CDD) headed by Professor Thomas Borody has cured Crohn's disease as reported today by Dr. Gaurav Agrawal in Gut Pathogens.
Apr 16, 2020
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Changes in the gut microbiome have long been linked with Crohn's disease and other forms of inflammatory bowel disease (IBD), but the biology behind those links has remained murky. Researchers at the Broad Institute, Massachusetts ...
Jun 11, 2019
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A new technique using patients' own modified cells to treat Crohn's disease has been proven to be effective in experiments using human cells, with a clinical trial of the treatment expected to start in the next six months.
Feb 15, 2019
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Two new treatments for Crohn's disease showed roughly equal performance in a clinical trial, according to findings published in The Lancet.
Jul 18, 2022
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Researchers estimate that more than half a million people in the U.S. have Crohn's disease, and 600,000 to 900,000 people in the U.S. have ulcerative colitis, according to the National Institute of Diabetes and Digestive ...
Dec 5, 2022
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First reported in ancient China, human fecal transplants have made a comeback in modern medicine. Evidence shows this treatment can be effective in treating C. difficile—a gastrointestinal infection that can cause symptoms ...
Apr 6, 2020
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Crohn's disease, also known as regional enteritis, is a type of inflammatory bowel disease that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea (which may be bloody if inflammation is at its worst), vomiting (can be continuous), or weight loss, but may also cause complications outside the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration.
Crohn's disease is caused by interactions between environmental, immunological and bacterial factors in genetically susceptible individuals. This results in a chronic inflammatory disorder, in which the body's immune system attacks the gastrointestinal tract possibly directed at microbial antigens.
Crohn's disease has traditionally been described as an autoimmune disease, but recent investigators have described it as a disease of immune deficiency.
There is a genetic association with Crohn's disease, primarily with variations of the NOD2 gene and its protein, which senses bacterial cell walls. Siblings of affected individuals are at higher risk. Males and females are equally affected. Smokers are two times more likely to develop Crohn's disease than nonsmokers. Crohn's disease affects between 400,000 and 600,000 people in North America. Prevalence estimates for Northern Europe have ranged from 27–48 per 100,000. Crohn's disease tends to present initially in the teens and twenties, with another peak incidence in the fifties to seventies, although the disease can occur at any age. There is no known pharmaceutical or surgical cure for Crohn's disease. Treatment options are restricted to controlling symptoms, maintaining remission, and preventing relapse.
The disease was named after American gastroenterologist Burrill Bernard Crohn, who, in 1932, together with two colleagues, described a series of patients with inflammation of the terminal ileum, the area most commonly affected by the illness.
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