Mitochondria, long known as "cellular power plants" for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety ...
Mar 27, 2014
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(Medical Xpress)—Neurodegenerative diseases like Parkinson's disease involve the death of thousands of neurons in the brain. Nerve growth factors produced by the body, such as GDNF, promote the survival of the neurons; ...
Jan 30, 2014
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Scientists at The Scripps Research Institute (TSRI) have discovered a natural mechanism that cells use to protect mitochondria, the tiny but essential "power plants" that provide chemical energy for cells throughout the body. ...
Dec 3, 2013
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New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone ...
Mar 14, 2013
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(HealthDay)—Cartilage from osteoarthritis patients shows greater oxidative damage and mitochondrial dysfunction than healthy cartilage, which is associated with the downregulation of the superoxide dismutase 2 (SOD2) gene, ...
Nov 19, 2012
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Mitochondria -- subunits inside cells that produce energy -- have long been thought to play a role in Alzheimer's disease. Now Mayo Clinic researchers using genetic mouse models have discovered that mitochondria in the brain ...
Feb 29, 2012
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Researchers at Rush University Medical Center are conducting an early phase clinical trial of a novel drug therapy for patients with dementia due to Alzheimer's disease. The drug is a new compound called MSDC-0160, which ...
Feb 15, 2012
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Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...
Jan 20, 2012
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