Medical research
Trial of gene therapy for sickle cell disease halted
A clinical trial of a new gene therapy for sickle cell disease that has shown promise has been halted after two participants were diagnosed with cancer.
Feb 24, 2021
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Myelodysplastic Syndrome
Medical research
Researchers build first model acute myeloid leukemia progression using CRISPR
A research team led by the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) has built the first cellular model to depict the evolution of acute myeloid leukemia (AML), from its early to late stages. By using gene ...
Feb 10, 2021
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Medications
Unravelling the multifaceted mechanisms of cancer cell death by mutant p53 targeting compound APR-246
Sophia Ceder and Klas Wiman and their colleagues at Department of Oncology-Pathology have together with researchers from Peter MacCallum Cancer Center, University of Melbourne, University of Cambridge and Aprea Therapeutics ...
Dec 18, 2020
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Oncology & Cancer
Stem cell transplant benefits older adults with MDS
(HealthDay)—Among older patients with myelodysplastic syndrome (MDS), survival rates are better for those undergoing allogeneic hematopoietic cell transplantation (HCT), according to a study presented at the annual meeting ...
Dec 8, 2020
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Oncology & Cancer
Trial will test existing drugs against rare blood cancer
A clinical trial designed to test existing drugs in the treatment of a rare blood cancer has been launched at the Universities of Warwick and Birmingham.
Oct 27, 2020
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Oncology & Cancer
Effects of acute and chronic graft-versus-myelodysplastic syndrome on outcomes following cell transplantation
Myelodysplastic syndrome (MDS) is a bone marrow failure disorder characterized by intractable cytopenia and dysplastic hematological changes. MDS has a varied clinical course, with some patients remaining asymptomatic with ...
Oct 7, 2020
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Oncology & Cancer
'Dietary' vulnerability found in cancer cells with mutated spliceosomes
A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes. ...
Oct 3, 2019
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Oncology & Cancer
Researchers develop new genetics-based prognostic tool for myelodysplastic syndrome
Researchers at Mayo Clinic have developed a new genetics-based prognostic tool for myelodysplastic syndrome. Their findings are published in the October print issue of Mayo Clinic Proceedings.
Oct 1, 2018
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Oncology & Cancer
Response to lenalidomide often suboptimal in MDS/MPN-RS-T
(HealthDay)—Lenalidomide produces hematologic responses in myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) with ring sideroblasts (RS) and thrombocytosis (MDS/MPN-RS-T), although these responses are often ...
Nov 1, 2017
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Oncology & Cancer
Mysterious gene transcripts after cancer therapy
Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of cancer. As opposed ...
Jun 12, 2017
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