Immunology
Harnessing the power of a parasite that can stop pain
For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.
Nov 30, 2023
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Visceral Leishmaniasis
Diseases, Conditions, Syndromes
Discovery of a new potential treatment for visceral leishmaniasis
A new preclinical candidate drug with the potential to treat visceral leishmaniasis, one of the world's major neglected diseases, has been discovered through a close collaboration between the University of Dundee, GSK and ...
Jul 25, 2018
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Diseases, Conditions, Syndromes
As 'flesh-eating' Leishmania come closer, a vaccine against them does, too
Parasites that ulcerate the skin, can disfigure the face, and may fatally mutilate its victim's internal organs are creeping closer to the southern edges of the United States.
Sep 13, 2017
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Diseases, Conditions, Syndromes
Arsenic in India's water could cause resistance to visceral leishmaniasis treatment
(Medical Xpress)—Every year, visceral leishmaniasis infects about 500,000 people and kills about 41,000. Most deaths occur in India's Bihar region, where there is a high level of resistance to the antimony compounds used ...
Genetics
Genetics discovery to help fight 'black fever'
Scientists—including a geneticist at The University of Western Australia—are a step closer to developing a vaccine against a fatally infectious parasite carried in the bite of sandflies.
Jan 8, 2013
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Diseases, Conditions, Syndromes
Test detects co-infection by novel species of parasite in severe cases of visceral leishmaniasis
In recent years, physicians and scientists in parts of Brazil where visceral leishmaniasis (VL) is endemic have seen rising numbers of cases of co-infection by Leishmania infantum and Crithidia, also a protozoan but hitherto ...
Nov 2, 2023
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Diseases, Conditions, Syndromes
New study provides 'genetic fingerprint' indicating disease spread by sand flies may be on the rise in US
Scientists have new evidence that a tropical disease once seen almost exclusively in returning travelers is now being detected in the United States in people with no international travel history—and caused by a Leishmania ...
Oct 19, 2023
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Diseases, Conditions, Syndromes
Co-infection by novel species of parasite is confirmed in visceral leishmaniasis patient
The first case of concomitant visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis in the same patient has been reported recently by researchers at the Federal University of São Carlos (UFSCar) in São Paulo ...
Aug 8, 2023
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Diseases, Conditions, Syndromes
Eliminating neglected diseases in Africa: There are good reasons for hope
Togo had reason to celebrate in 2022 when it became the first country in the world to eliminate four neglected tropical diseases. The west African nation stamped out Guinea worm disease in 2011, lymphatic filariasis in 2017, ...
Jan 27, 2023
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Medications
Better, shorter combination treatment for people with visceral leishmaniasis shown to be effective in Eastern Africa
A shorter, and less toxic treatment for people with visceral leishmaniasis was shown to be effective thanks to a study conducted in Eastern Africa by the non-profit medical research organization Drugs for Neglected Diseases ...
Sep 29, 2022
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Visceral leishmaniasis (VL), also known as kala-azar, black fever, and Dumdum fever,:426 is the most severe form of leishmaniasis. Leishmaniasis is a disease caused by protozoan parasites of the Leishmania genus. This disease is the second-largest parasitic killer in the world (after malaria), responsible for an estimated 500,000 cases each year worldwide. The parasite migrates to the internal organs such as liver, spleen (hence 'visceral') and bone marrow, and, if left untreated, will almost always result in the death of the host. Signs and symptoms include fever, weight loss, mucosal ulcers, fatigue, anemia and substantial swelling of the liver and spleen. Of particular concern, according to the World Health Organization (WHO), is the emerging problem of HIV/VL co-infection.
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