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Immunology news

Oncology & Cancer

Study finds estrogens play a hidden role in cancers, inhibiting a key immune cell

Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study by Duke Cancer Institute researchers unexpectedly finds that estrogens play a role in fueling the growth of breast ...

Immunology

Research reveals mechanism of effector-triggered immunity

A pair of studies examining immune response in C. elegans reveal broad implications for understanding pathogen detection in higher animals and the evolutionary origins of immunity itself.

Immunology

Circadian rhythm disruption linked to lung inflammation

In a study published in the journal Frontiers in Immunology, researchers at the University of Arizona Health Sciences Center for Sleep, Circadian and Neuroscience research have explored the effects of circadian rhythm disruption ...

HIV & AIDS

'Undetectable' HIV patients could hold key to treatments

A rare group of HIV-positive people who maintain undetectable levels of the virus in their blood without medication could hold the key to new therapies for others living with the disease, says a leading genome expert.

Immunology

Novel antibodies against Klebsiella pneumoniae identified

Research at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. Using genetic and functional approaches, the researchers also managed ...

Immunology

Nanobodies help decode the central mechanism of inflammation

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...

Diseases, Conditions, Syndromes

An eye on viruses in wastewater: Q&A with virologist

Virologist Rúbens Alves, Ph.D., came to La Jolla Institute for Immunology (LJI) to contribute to life-saving vaccine research. As a member of LJI's Shresta Lab, Alves studied how T cells fight viruses such as SARS-CoV-2 ...

Immunology

Researchers discover new role of immune cells in eye health

The eye is an immune-privileged tissue because of the need to keep blood vessels away from the central pathway of light and to restrict entry of inflammatory cells that could cause damage. This has prompted questions about ...

Oncology & Cancer

B-cells hold promise for treating glioblastoma

Harnessing the body's B-cells to fight tumors may be a promising treatment for glioblastoma, according to a Northwestern Medicine study recently published in the Journal of Clinical Investigation.

Health

Q&A: The rising rates of immunosuppression among US adults

Early in the COVID-19 pandemic, as it became clear that people with suppressed immune systems were particularly vulnerable to the worst of the virus, public health officials prioritized their protection. Leaders presented ...

Diseases, Conditions, Syndromes

Scientists find weak points on Epstein-Barr virus

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this ...

Oncology & Cancer

Lung cancer treatment shows promise in tumor models

A molecule has demonstrated its ability to kill tumor cells and incite an immune response in preclinical models of small cell lung cancer (SCLC), according to UT Southwestern Medical Center researchers. The findings, published ...

Immunology

Key protein linked to immune disorders

A new study has shed light on the importance of the protein STAP-1 in activating certain immune cells. Understanding the role of STAP-1 in these cells could give researchers a better glimpse into immune-related disorders ...

Cardiology

Exploring how the liver immune system eats up 'bad cholesterol'

A new study from Karolinska Institutet in Sweden reveals that immune cells in the liver react to high cholesterol levels and eat up excess cholesterol that can otherwise cause damage to arteries. The findings, published in ...

Oncology & Cancer

Protein 'brake' could help develop new cancer treatments

Some cancerous tumors hijack proteins that act as "brakes" on our immune system and use them to form a sort of shield against immune recognition. Immunotherapy treatments have been created that turn off these "brakes" and ...

Neuroscience

Why is the brain so prone to inflammation?

All living cells teem with ribonucleic acid (RNA), molecules that relay genetic messages to keep cells functioning. But these necessary molecules can also set off cellular alarms. The long twisted-together strands of RNA ...