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Inflammatory disorders news
Immunology
New insights into the control of inflammation
Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...
Jan 13, 2021
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Health
Low fitness linked to higher psoriasis risk later in life
In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. ...
Jan 12, 2021
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Opening a new door into kinder, gentler therapies for chronic inflammation
A naturally occurring antibody capable of stimulating the body's immune-suppressing regulatory T cells has been discovered by a team of Harvard scientists, a finding that may eventually open a new door into kinder, gentler ...
The two sides of inflammation—the cure and the curse
One of the many wonders—and mysteries—of human biology is the complex response of the innate immune system, which is known for its swiftness in annihilating invading pathogens and capacity to mount an explosive inflammatory ...
Patients with psoriasis shoulder substantial psychological burden
(HealthDay)—Patients with psoriasis have a considerable psychological burden, according to a study published online Dec. 22 in The Journal of Dermatology.
Dec 28, 2020
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Scientists identify genetic risks of rare inflammatory disease
In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of Medicine identified new genetic associations that ...
Dec 11, 2020
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Analysis of data collected from clinic reproduced psoriasis drug trial results
The difference in effect of two drugs commonly used to treat psoriasis was reliably reproduced from a clinical trial by a large observational study carried out by University of Manchester and Salford Royal NHS Foundation ...
Dec 10, 2020
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New study finds fish oil omega-3s EPA and DHA work differently on chronic inflammation
The omega-3 fatty acids EPA and DHA work differently against chronic inflammation, according to the results of a small randomized study, suggesting each has its own important role to play in regulating the immune system.
Dec 07, 2020
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What makes psoriasis sore: Novel role of immune system in the disease
More than 130 million people around the globe suffer from psoriasis vulgaris, a chronic condition characterized by skin inflammation, scales, and dry patches. However, its pathology is not fully clear. In a recent study, ...
Dec 03, 2020
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Research reveals how a fungal infection activates inflammation
Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, ...
Dec 02, 2020
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Adverse pregnancy outcomes up for women with psoriasis
(HealthDay)—Pregnancies in women with psoriasis have an increased risk for adverse outcomes, including preeclampsia and stillbirth, according to a study published online Nov. 18 in the Journal of Dermatology.
Dec 01, 2020
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Study reveals the impact of systemic inflammation on disease progression
Every year, liver cirrhosis is responsible for approximately 170,000 deaths in Europe and recent epidemiological data show Austria to be in second place in regard to prevalence of cirrhosis in Europe. Excessive alcohol consumption, ...
Nov 30, 2020
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Potential new target to combat inflammatory diseases
An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19.
Nov 19, 2020
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Chronic inflammation causes a reduction in NAD+
NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has ...
Nov 16, 2020
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Study pinpoints target for managing inflammation, promoting tissue repair
Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new study led by experts at Cincinnati Children's.
Nov 16, 2020
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Two anti-inflammatory compounds shown to be capable of accelerating recovery from COVID-19
Two independent clinical studies—one by researchers at the Center for Cell-Based Therapy (CTC) in Ribeirão Preto, state of São Paulo (Brazil), on the monoclonal antibody eculizumab, and the other by scientists at the ...
Nov 16, 2020
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People with inflammatory bowel disease still die earlier despite increase in life
A study comparing life expectancy of people with inflammatory bowel disease (IBD) and without found that, while life expectancy increased for both groups, people with IBD generally died sooner. The study is published in CMAJ ...
Nov 09, 2020
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COVID-19: Enzyme targeted by virus also influences gut inflammation
An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the ...
Nov 05, 2020
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New cause of inflammation in people with HIV identified
While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans—by up to five to 10 years—compared to ...
Oct 30, 2020
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Smoking has negative effects for patients with psoriasis
(HealthDay)—For patients with psoriasis, smoking has negative effects, including increased frequency of nail involvement and cardiovascular diseases and higher psoriasis area and severity index, according to a study published ...
Oct 30, 2020
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