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Inflammatory disorders news

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Health

Low fitness linked to higher psoriasis risk later in life

In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. ...

Inflammatory disorders

The two sides of inflammation—the cure and the curse

One of the many wonders—and mysteries—of human biology is the complex response of the innate immune system, which is known for its swiftness in annihilating invading pathogens and capacity to mount an explosive inflammatory ...

Genetics

Scientists identify genetic risks of rare inflammatory disease

In a paper published today in the American Journal of Human Genetics, a group of international collaborators led by researchers from the University of Pittsburgh School of Medicine identified new genetic associations that ...

Immunology

Research reveals how a fungal infection activates inflammation

Scientists at St. Jude Children's Research Hospital have identified the mechanisms behind inflammasome activation driven by infection with the fungal pathogen Aspergillus fumigatus. Fungal infection, especially with A. fumigatus, ...

Obstetrics & gynaecology

Adverse pregnancy outcomes up for women with psoriasis

(HealthDay)—Pregnancies in women with psoriasis have an increased risk for adverse outcomes, including preeclampsia and stillbirth, according to a study published online Nov. 18 in the Journal of Dermatology.

Medical research

Potential new target to combat inflammatory diseases

An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19.

Medical research

Chronic inflammation causes a reduction in NAD+

NAD+ (nicotinamide adenine dinucleotide), a key metabolite central to an efficient and healthy metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has ...

Inflammatory disorders

COVID-19: Enzyme targeted by virus also influences gut inflammation

An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the ...

HIV & AIDS

New cause of inflammation in people with HIV identified

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans—by up to five to 10 years—compared to ...

Inflammatory disorders

Smoking has negative effects for patients with psoriasis

(HealthDay)—For patients with psoriasis, smoking has negative effects, including increased frequency of nail involvement and cardiovascular diseases and higher psoriasis area and severity index, according to a study published ...

Diseases, Conditions, Syndromes

Computer model shows how COVID-19 could lead to runaway inflammation

A study from the University of Pittsburgh School of Medicine and Cedars-Sinai addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation? The research shows how the molecular structure ...

Medical research

Cell therapy designed to treat inflammatory bowel disease

The UPV/EHU's NanoBioCel research group is developing systems that enable cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. ...

Cardiology

Impact of psoriasis explored for hospital outcomes of acute MI

(HealthDay)—Myocardial infarction (MI) events may occur earlier in life in patients with psoriasis, which in turn may affect hospital outcomes, according to a study published online Sept. 11 in the Journal of the American ...

Inflammatory disorders

Antibiotic pre-treatment reduces joint inflammation

Tearing an anterior cruciate ligament (ACL) can be an excruciatingly painful injury. Nearly 50 percent of these patients will develop a secondary form of osteoarthritis, deemed post-traumatic osteoarthritis (PTOA).

Medications

Adding belimumab improves renal outcome in lupus nephritis

(HealthDay)—The addition of belimumab versus placebo to standard therapy increases the likelihood of a primary efficacy renal response in patients with active lupus nephritis, according to a study published in the Sept. ...

Inflammatory disorders

New imaging agent spotlights inflammation

Many of the most common diseases—cancer, diabetes, cardiovascular and lung disease, and even COVID-19—have been linked to chronic or excessive inflammation. Blood tests can indicate that some part of a person's body is ...

Medications

Common diabetes drug reverses inflammation in the liver

The diabetes drug metformin—derived from a lilac plant that's been used medicinally for more than a thousand years—has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 ...

Inflammatory disorders

Shift seen to newer agents to treat psoriasis

(HealthDay)—Phototherapy use for psoriasis decreased from 2005 to 2018, while use of biologics increased, according to a research letter published online Sept. 4 in Dermatologic Therapy.

Alzheimer's disease & dementia

Study links inflammation to Alzheimer's disease development

Alzheimer's disease is a neurodegenerative condition that is characterized by the buildup of clumps of beta-amyloid protein in the brain. Exactly what causes these clumps, known as plaques, and what role they play in disease ...

Cardiology

Severe COVID-19 associated with heart issues

The number of people coronavirus disease 2019 (COVID-19) is rising with more cases in the U.S. (5M according to the Centers for Disease Control and Prevention, CDC) than any other country (20M confirmed cases worldwide, according ...

Inflammatory disorders

Q&A: Controlling 'inflammaging,' inflammation that occurs with aging

A team at the CRCHUM—Université de Montréal's hospital research center—has discovered a new function for proteins responsible for DNA repair in the control of an inflammatory response in aging cells, also known as senescent ...