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Inflammatory disorders news

Diseases, Conditions, Syndromes

Prevalence data suggest increasing trend of psoriasis with age

A clear bimodal age pattern exists in psoriasis onset, and prevalence shows an increasing trend with age until 60 or 70 years, according to a review published in the February issue of the British Journal of Dermatology.

Oncology & Cancer

How inflammatory signalling molecules contribute to carcinogenesis

A team of MedUni Vienna researchers led by Johannes A. Schmid at the Center for Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, has managed to identify a previously unknown molecular connection ...

Inflammatory disorders

Child proton pump inhibitor use may increase asthma risk

Initiation of proton pump inhibitor (PPI) use is associated with an increased risk for asthma among children compared with nonuse, according to a study published online Feb. 8 in JAMA Pediatrics.

Inflammatory disorders

Scientists switch on tissue repair in inflammatory bowel disease

A method that instructs immune system cells to help repair damaged tissues in the intestine has been developed by researchers at KU Leuven and Seoul National University. This opens the way for more effective treatment of ...

Cardiology

Uncovering a link between inflammation and heart disease

Inflammation is part of an immune response to fight off pathogens and clear infections. But patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present.

Inflammatory disorders

In survey of those with uncontrolled asthma, half smoked cannabis

As the number of states increase where medical and recreational cannabis use is legal, so does the importance that physicians discuss with patients the effects of cannabis on those with asthma. A new survey in Annals of Allergy, ...

Cardiology

New weapon for inflammation

Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases.

Medications

Sickle cell target could treat COVID

Scientists have found a way to lower stroke risk in sickle cell patients that opens a gateway of potential treatments for inflammation and clotting stemming from conditions such as COVID-19. For the first time, they investigated ...

Inflammatory disorders

Some inflammatory diseases linked to stroke-associated pneumonia

(HealthDay)—For patients discharged after acute ischemic stroke (AIS), the risk for stroke-associated pneumonia (SAP) is reduced for those with psoriasis or other chronic inflammatory diseases, according to a study published ...

Immunology

Exercising muscle combats chronic inflammation on its own

Biomedical engineers at Duke University have demonstrated that human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised. The discovery was made possible through the use of ...

Immunology

New insights into the control of inflammation

Scientists at The Wistar Institute discovered that Early Growth Response 1 (EGR1), a protein that turns on and off specific genes during blood cell development, inhibits expression of pro-inflammatory genes in macrophages. ...

Health

Low fitness linked to higher psoriasis risk later in life

In a major register-based study, scientists at University of Gothenburg, Sweden, have now demonstrated a connection between inferior physical fitness in young adults and elevated risk of the autoimmune disease psoriasis. ...

Inflammatory disorders

Antibiotic pre-treatment reduces joint inflammation

Tearing an anterior cruciate ligament (ACL) can be an excruciatingly painful injury. Nearly 50 percent of these patients will develop a secondary form of osteoarthritis, deemed post-traumatic osteoarthritis (PTOA).

Medications

Adding belimumab improves renal outcome in lupus nephritis

(HealthDay)—The addition of belimumab versus placebo to standard therapy increases the likelihood of a primary efficacy renal response in patients with active lupus nephritis, according to a study published in the Sept. ...

Inflammatory disorders

New imaging agent spotlights inflammation

Many of the most common diseases—cancer, diabetes, cardiovascular and lung disease, and even COVID-19—have been linked to chronic or excessive inflammation. Blood tests can indicate that some part of a person's body is ...

Medications

Common diabetes drug reverses inflammation in the liver

The diabetes drug metformin—derived from a lilac plant that's been used medicinally for more than a thousand years—has been prescribed to hundreds of millions of people worldwide as the frontline treatment for type 2 ...

Inflammatory disorders

Shift seen to newer agents to treat psoriasis

(HealthDay)—Phototherapy use for psoriasis decreased from 2005 to 2018, while use of biologics increased, according to a research letter published online Sept. 4 in Dermatologic Therapy.

Alzheimer's disease & dementia

Study links inflammation to Alzheimer's disease development

Alzheimer's disease is a neurodegenerative condition that is characterized by the buildup of clumps of beta-amyloid protein in the brain. Exactly what causes these clumps, known as plaques, and what role they play in disease ...

Cardiology

Severe COVID-19 associated with heart issues

The number of people coronavirus disease 2019 (COVID-19) is rising with more cases in the U.S. (5M according to the Centers for Disease Control and Prevention, CDC) than any other country (20M confirmed cases worldwide, according ...

Inflammatory disorders

Q&A: Controlling 'inflammaging,' inflammation that occurs with aging

A team at the CRCHUM—Université de Montréal's hospital research center—has discovered a new function for proteins responsible for DNA repair in the control of an inflammatory response in aging cells, also known as senescent ...

Immunology

The yin and yang of inflammation controlled by a single molecule

Researchers from the Perelman School of Medicine at the University of Pennsylvania have now identified a protein called histone deacetylase 3 (HDAC3) as the orchestrator of the immune system's inflammation response to infection. ...

Diseases, Conditions, Syndromes

Inflammation tied to thyroid dysfunction with psoriasis

(HealthDay)—Thyroid dysfunction in patients with psoriasis may be associated with inflammation caused by psoriasis, according to a study published online June 22 in the Journal of Dermatology.

Inflammatory disorders

Researchers develop new treatment method for psoriasis

Psoriasis, a chronic skin condition that causes itchy, red, scaly patches, afflicts more than 8 million Americans and 125 million people worldwide. Small molecule-based drugs like steroids can penetrate the skin to treat ...