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Inflammatory disorders news

Diseases, Conditions, Syndromes

Home-based phototherapy as effective as office-based for psoriasis

For plaque or guttate psoriasis, home-based narrowband ultraviolet B phototherapy is as effective as office-based phototherapy, according to a study published online Sept. 25 in JAMA Dermatology to coincide with the annual ...

Inflammatory disorders

Thaumatin, a natural sweetener with anti-inflammatory potential

A new study by the Leibniz Institute for Food Systems Biology at the Technical University of Munich shows for the first time that bitter tasting protein fragments (peptides) are produced in the stomach during the digestion ...

Immunology

Nanobodies help decode the central mechanism of inflammation

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine ...

Medications

FDA approves Bimzelx for three new indications

The U.S. Food and Drug Administration has approved Bimzelx (bimekizumab-bkzx) for the treatment of adults with active psoriatic arthritis (PsA), adults with active nonradiographic axial spondyloarthritis (nr-axSpA) with objective ...

Diseases, Conditions, Syndromes

Houston pollen count has spiked dramatically over the last decade

New data from the Houston area reveals spiking levels of ragweed, elm and cedar elm pollen as well as mold spore counts as we enter the fall season. An allergy expert at Baylor College of Medicine breaks down this information ...

Inflammatory disorders

FDA approves Tremfya for ulcerative colitis

The U.S. Food and Drug Administration has approved Johnson & Johnson's Tremfya (guselkumab) for the treatment of adults with moderately to severely active ulcerative colitis.

Inflammatory disorders

Diagnostic tool identifies puzzling inflammatory diseases in kids

RNA performs a number of biological duties, from delivering genetic information to manufacturing proteins. But RNA is also expelled from cells via cell death or active release, and can then find its way into blood plasma.

Immunology

Cells that destroy the intestine

Patients affected by the chronic inflammatory bowel diseases morbus Crohn and ulcerative colitis often suffer from flare-ups, which damage intestinal tissue. Despite advances in treating these diseases with medication, associated ...

Alzheimer's disease & dementia

Identification of a central regulator

A new study by LMU researchers shows that the protein ApoE plays a key role in the pathogenesis of diseases associated with chronic inflammation, and identifies a new target for therapeutic strategies against atherosclerosis ...

Oncology & Cancer

Scientists find link between inflammation and cancer

Severe inflammation in tissues is often associated with the occurrence of cancer. The mechanism linking both these conditions is not clearly understood. Furthermore, inflamed and cancerous tissues contain a heterogenous mix ...

Immunology

Discovery of bacterial signature of intestinal disease

Researchers from the Department of Biomedical Research of the University of Bern and the University Clinic of Visceral Surgery and Medicine of the Inselspital Bern, Switzerland, have discovered that changes in the composition ...

Immunology

Study finds unique form of chronic sinusitis in older patients

Older patients with a diagnosis of chronic sinusitis—a disease of the nasal cavity and paranasal sinuses that often persists over many years—have a unique inflammatory signature that may render them less responsive to ...

Immunology

Researchers discover new immune response regulators

The research groups of Academy Professor Riitta Lahesmaa and Research Director Laura Elo from Turku Centre for Biotechnology have discovered new proteins that regulate T cells in the human immune system. Some of these proteins ...

Immunology

A molecular switch for stopping inflammation

A component has been identified by researchers in Umeå as a novel regulator of the immune system. It acts as a molecular switch to deactivate the innate immune system and has the ability to prevent certain diseases caused ...

Immunology

Scientists develop new mouse model of Hirschsprung's disease

About one in every 5,000 babies is born without enteric neurons in the distal colon resulting in Hirschsprung's disease. Because of the missing neurons, contents of the gut cannot pass normally, resulting in constipation ...

Diseases, Conditions, Syndromes

Classification of psoriasis severity depends on definition

(HealthDay)—Depending on the definition used, there are large variations in the proportion of patients identified as having moderate-to-severe psoriasis, according to a study published in the December issue of the British ...

Psychology & Psychiatry

Negative mood signals body's immune response

Negative mood—such as sadness and anger—is associated with higher levels of inflammation and may be a signal of poor health, according to researchers at Penn State.

Diseases, Conditions, Syndromes

Sequencing gut microbes shows differences between IBD and IBS

A team of researchers with members from the Netherlands and the U.S. has found differences in the numbers of gut microbes for patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In their paper ...

Medical research

Cohesin down-regulation drives hematopoietic stem cell aging

Aging is characterized by increases in inflammation and decreases in stem cell function. The relationship between these processes remains incompletely understood. Researchers of the Leibniz Institute on Aging (FLI) in Jena, ...

Inflammatory disorders

PM2.5 exposure linked to asthma rescue medication use

(HealthDay)—For individuals with asthma, increased fine particulate matter (PM2.5) exposure is associated with increased weekly rescue inhaler use, according to a study published online Nov. 26 in the Proceedings of the ...

Inflammatory disorders

Next-generation asthma inhalers

In Europe alone, there are almost 30 million people who suffer from asthma. The myAirCoach project provides an innovative smart inhaler device along with integrated mobile Health (mHealth) personalised asthma monitoring services ...