The liver is crucial for the detoxification of the human body. The exposure to toxins makes it particularly prone to drug-induced injury. Cholestasis, the impairment of bile flow, is therefore a common problem of drug development ...
Mar 27, 2017
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Columbia University Medical Center (CUMC) researchers have discovered a common genetic variant that greatly impacts normal brain aging, starting at around age 65, and may modify the risk for neurodegenerative diseases. The ...
Mar 15, 2017
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Parkinson's disease (PD) and other "synucleinopathies" are known to be linked to the misfolding of alpha-synuclein protein in neurons. Less clear is how this misfolding relates to the growing number of genes implicated in ...
Jan 25, 2017
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Scientists have revealed how cancer cells are able to break free of the physical restraints imposed by their surroundings in order to grow and spread around the body.
Jan 5, 2017
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In Alzheimer's research, one particular protein looms large: plaque-forming amyloid-beta. Yet doctors now recognize that plaques can accumulate decades before symptoms appear. Recent clinical trials aimed at controlling or ...
Dec 15, 2016
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In an important step in the battle against osteoporosis, a serious brittle bone disease that affects millions, researchers have identified more than a dozen genes amid the vast human genome likely responsible for bone density ...
Dec 14, 2016
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While it is well known that cigarette smoking is a major cause of lung disease, and a key exacerbating factor for patients suffering from chronic obstructive pulmonary disease (COPD), it has not been possible to effectively ...
Oct 27, 2016
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An assessment blending several measures of immune-cell responsiveness predicted cardiovascular problems in individuals who likely would have slipped under the radar.
Oct 14, 2016
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The skin is the largest organ in mammals and it serves to protect the body from outside influences, such as physical damage, radiation, fluid loss or extreme temperatures. To fulfill this function, a plethora of cell types ...
Oct 4, 2016
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Genome-wide association studies, which try to find correlations between particular genetic variations and disease diagnoses, are a staple of modern medical research.
Aug 9, 2016
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