Disease Models & Mechanisms

Diabetes

Diabetes-associated pain linked to disrupted insulin signalling

The chronic pain experienced by a number of patients with diabetes has widely been assumed to originate from damage to blood vessels or to local tissue surrounding neurons caused by high blood-sugar levels. However, a new ...

Medical research

Scientists search for the clocks behind aging brain disorders

To understand the link between aging and neurodegenerative disorders such as Alzheimer's disease, scientists from the National Institutes of Health compared the genetic clocks that tick during the lives of normal and mutant ...

Neuroscience

DMM launches new special collection on neurodegeneration

A growing aging population means that age-dependent neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are affecting increasing numbers of ...

Diseases, Conditions, Syndromes

Novel syndrome highlights the importance of rare disease research

A group of researchers from Pakistan, Europe and Singapore have identified and characterised a previously undiscovered rare deafness-dystonia syndrome in a family living in a remote region of Pakistan. The research, published ...

Diseases, Conditions, Syndromes

Signaling pathways in the pathogenesis of diamond blackfan anemia

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer. Current treatment options, including ...

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