Disease Models & Mechanisms

Medical research

Early intervention may hold key to treatment of Friedreich's ataxia

Current treatments may be administered too late to target Friedreich's ataxia effectively. New research using a slow-onset frataxin knock-in/knockout mouse model showed significantly reduced levels of mitochondrial biosynthesis ...

Neuroscience

DMM launches new special collection on neurodegeneration

A growing aging population means that age-dependent neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis are affecting increasing numbers of ...

Diseases, Conditions, Syndromes

Novel syndrome highlights the importance of rare disease research

A group of researchers from Pakistan, Europe and Singapore have identified and characterised a previously undiscovered rare deafness-dystonia syndrome in a family living in a remote region of Pakistan. The research, published ...

Diseases, Conditions, Syndromes

Signaling pathways in the pathogenesis of diamond blackfan anemia

Diamond Blackfan Anemia (DBA) is a condition that is characterized by a failure of the bone marrow to produce red blood cells, congenital abnormalities, and a predisposition to cancer. Current treatment options, including ...

Medical research

Study establishes zebrafish as a model for flu study

In the ongoing struggle to prevent and manage seasonal flu outbreaks, animal models of influenza infection are essential to gaining better understanding of innate immune response and screening for new drugs. A research team ...

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