Genome Research

Genetics

Human disease epigenomics 2.0

The study of how genes are regulated and how their regulation affects human disease has the potential to generate insights into mechanisms that aren't based on variation in DNA sequence, and could even show that temporally ...

Neuroscience

Can we cure Huntington's disease?

I didn't cry until page 123 of Lisa Genova's terrific new novel Inside the O'Briens. That's when 44-year-old Boston police officer Joe O'Brien tells his four young adult offspring that his "weird temper"; his frequent toe-tapping, ...

Genetics

PopPUNK advances speed of bacterial pathogen surveillance

Differences in genetic diversity among bacterial pathogens correlate with clinically important factors, such as virulence and antimicrobial resistance, prompting the need to identify clusters of similar bacterial strains. ...

Genetics

Systematic interaction network filtering in biobanks

While seeking targets to attack Huntington's disease, an incurable inherited neurodegenerative disorder, neurobiologists of the research group led by Professor Erich Wanker of the Max Delbrück Center for Molecular Medicine ...

Genetics

Cancer-preventing protein finds its own way in our DNA

Geneticists from KU Leuven, Belgium, have shown that tumour protein TP53 knows exactly where to bind to our DNA to prevent cancer. Once bound to this specific DNA sequence, the protein can activate the right genes to repair ...

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