Journal of Biological Chemistry

Medical research

Vitamin A deficiency may be involved in type 2 diabetes

Investigators have long sought the answer to a vexing question: What are the biological mechanisms involved in the development of type 2 diabetes? A recent study from Weill Cornell Medical College researchers suggests that ...

Genetics

Protein mutation alters tissue development in males before birth

Case Western Reserve researchers have identified a protein mutation that alters specific gender-related tissue in males before birth and can contribute to the development of cancer as well as other less life-threatening challenges.

Genetics

Researchers offer first analysis of new human glucose disorder

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, ...

Oncology & Cancer

Discovery could lead to better head and neck cancer therapies

UCLA scientists have discovered that a protein usually linked to rare neurological disorders is also associated with head and neck cancer in people who are infected with the human papilloma virus. And when that protein is ...

Overweight & Obesity

Team pieces together signaling pathway leading to obesity

As scientists probe the molecular underpinnings of why some people are prone to obesity and some to leanness, they are discovering that weight maintenance is more complicated than the old "calories in, calories out" adage.

Medical research

New gene linked to blindness and Parkinson's disease

The retinal pigment epithelium (RPE) is a tissue, which lines the back of the eye. Aging, environmental (toxic) insults and genetic predispositions contribute to the death of RPE cells in diseases, such as age-related macular ...

Inflammatory disorders

New compounds reduce debilitating inflammation

Six Case Western Reserve scientists are part of an international team that has discovered two compounds that show promise in decreasing inflammation associated with diseases such as ulcerative colitis, arthritis and multiple ...

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