Journal of Experimental Medicine

Genetics

Insights into causes of rare genetic immune disorders

The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research. The disorder is caused by genetic variations ...

Genetics

New gene-editing technique reverses vision loss in mice

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans. The study, to be published March 17 in the Journal of Experimental Medicine, uses ...

Diseases, Conditions, Syndromes

Targeting type of B cell could reduce lupus disease, study suggests

A group of University of Pittsburgh researchers has given new meaning to "knowing your ABCs." In a new study, published in the Journal of Experimental Medicine, the team showed that a type of immune cell called age-associated ...

Medical research

Finding the best models for liver and kidney disease

In two separate studies, researchers at EPFL have carried out extensive tests to develop the best mouse models for studying kidney and liver diseases. The findings provide crucial insights into both conditions, and are expected ...

Medical research

Will revitalizing old blood slow aging?

Young blood has a rejuvenating effect when infused into older bodies, according to recent research: Aging hearts beat stronger, muscles become stronger, and thinking becomes sharper.

Medical research

Study shows how our brains can turn into smarter disease fighters

Combating Alzheimer's and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of ...

Immunology

How regulatory T cells halt aberrant, self-reactive T cells

New research findings show in detail how self-reactive T cells—white blood cells that mistakenly attack healthy instead of infected cells, thereby causing an autoimmune or an inflammatory response—are held in check by ...

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