Molecular Cell

Medical research

Why some cancers may respond poorly to key drugs discovered

Patients with BRCA1/2 mutations are at higher risk for breast, ovarian and prostate cancers that can be aggressive when they develop—and, in many cases, resistant to lifesaving drugs. Now scientists at The University of ...

Medications

Medication-based starvation of cancer cells

Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide, have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University ...

Oncology & Cancer

Nutty stimulant revealed as anticancer tool

Arecoline—the stimulant component of areca nuts—has anticancer properties, researchers at Winship Cancer Institute of Emory University have discovered.

Cardiology

Heart disease severity may depend on nitric oxide levels

The most common heart medications may get an assist from nitric oxide circulating in the body, according to a new study out of Case Western Reserve University School of Medicine. Researchers showed that nitric oxide may help ...

Medical research

Targeting bicarbonate in cancer

Bicarbonate ions are required for cell growth in some cancers, according to a Northwestern Medicine study published in the journal Molecular Cell.

Neuroscience

Research reveals atomic-level changes in ALS-linked protein

For the first time, researchers have described atom-by-atom changes in a family of proteins linked to amyotrophic lateral sclerosis (ALS), a group of brain disorders known as frontotemporal dementia and degenerative diseases ...

Diseases, Conditions, Syndromes

Mechanism underlying the emergence of virus variants unravelled

An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses. Hiccups during the ...

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