Experimental therapy eases Alzheimer's signs, symptoms in mice
A new cellular therapy improved learning and memory in mice with Alzheimer's disease, researchers report.
Dec 29, 2023
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Molecular Neurodegeneration is an open access, peer-reviewed online journal that encompasses all aspects of neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases collectively refer to neurological disorders that result from neurodegeneration and include, but are not limited to, Alzheimer's disease, Parkinson disease, Huntington disease, and prion diseases. These diseases, which are often associated with advanced aging and display varying degrees of dementia, have become a significant public health issue as humans live longer and the aging population grows larger. Recent advances in the molecular and cellular mechanisms underlying the pathogenesis of these neurodegenerative disorders have allowed for a better understanding of the disease mechanisms.
A new cellular therapy improved learning and memory in mice with Alzheimer's disease, researchers report.
Dec 29, 2023
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80
Researchers at Weill Cornell Medicine have demonstrated how amyloid beta, a peptide associated with Alzheimer's disease, can interact with a protein receptor on immune cells in the brain. This triggers a reaction that damages ...
Nov 8, 2023
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Researchers at St Vincent's Hospital in Sydney have achieved a breakthrough in our understanding dementia and new way forward to its treatment. Through their discovery, the team restored nerve cell connections (synapses) ...
Sep 28, 2023
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In the human central nervous system, there are tiny cells that—for most people, most of the time—provide important immune protection to the brain and spinal cord. Occasionally these microglia cells run terribly awry, ...
May 30, 2023
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Indiana University School of Medicine researchers are investigating how the deficiency of a gene in immune cells can shape the progression of Alzheimer's disease.
Nov 3, 2022
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More than a decade before people with Huntington's disease show symptoms, they can exhibit abnormally high levels of an immune-system molecule called interleukin-6 (IL-6), which has led many researchers to suspect IL-6 of ...
May 26, 2020
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New research points to tau, not amyloid-beta (Abeta) plaque, as the seminal event that spurs neuron death in disorders such as Alzheimer's disease. The finding, which dramatically alters the prevailing theory of Alzheimer's ...
Oct 31, 2014
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A new study shows that the activation of the brain's immune defense cells—astrocytes—in the early stages of Alzheimer's disease could be tracked early with a brain PET scanner and is linked to changes that can be detected ...
Sep 12, 2023
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To date, the search for effective treatments for dementia has yielded only disappointments. Many recent drug candidates target the tau protein, which aggregates and forms tangles in patients' brain tissue and is involved ...
Apr 7, 2023
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Alzheimer's disease (AD) currently has no cure and is predicted to affect over 100 million people worldwide by 2050. Ongoing research is focused on two key neurotoxic proteins: amyloid beta (Aβ) and tau. While these proteins ...
Oct 17, 2022
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