Nature Methods

Genetics

Breakthrough in detecting mutations in genomes of single cells

Einstein researchers have developed and validated a method for accurately identifying mutations in the genomes of single cells. The new method, which can help predict whether cancer will develop in seemingly healthy tissue, ...

Genetics

Scientists genetically decode rare kidney disease

When Dr. Bodo Beck first saw the three children of a family who had fled Syria sitting in his consultation room at University Hospital Cologne, the human geneticist was surprised. His genetic analysis diagnosed Bartter syndrome ...

Medical research

Blood biomarker detects COVID-19 severity and enables early triage

Dr. Kulasinghe, from QUT Centre for Genomics and Personalised Health and School of Biomedical Sciences, delivered the findings to a special virtual meeting of the American Association of Cancer Research (AACR) on "COVID-19 ...

Neuroscience

Enhanced AI tracks neurons in moving animals

Recent advances allow imaging of neurons inside freely moving animals. However, to decode circuit activity, these imaged neurons must be computationally identified and tracked. This becomes particularly challenging when the ...

Oncology & Cancer

Scientists take early step to personalized breast cancer care

UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of chemotherapy drugs.

Oncology & Cancer

Tapping the genome's social network to find cancer drivers

Any one tumor might harbor mutations in thousands of different genes. The challenge is to find the driver mutations—which fuel cancerous activity, and might be promising treatment targets—within the haystack of passengers ...

Immunology

Immunology meets single-cell sequencing

Research from the Single-Cell Genomics Centre on the Wellcome Genome Campus could change the way we look at gene expression and immune response. Published in Nature Methods, the new method, TraCeR, provides a powerful tool ...

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