Nature Methods

Oncology & Cancer

Current cancer drug discovery method flawed, study finds

The primary method used to test compounds for anti-cancer activity in cells is flawed, Vanderbilt University researchers report May 2 in Nature Methods. The findings cast doubt on methods used by the entire scientific enterprise ...

Neuroscience

A three-photon microscope for capturing deep-brain images

A research team at China's Peking University has made a new breakthrough in multiphoton microscopy by developing a miniature three-photon microscope that has successfully captured deep-brain images of freely moving mice.

Oncology & Cancer

Advancing the study of T cells to improve immunotherapy

UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer.

Neuroscience

A one-stop-shop for brain imaging

The brain is a complex organ, and no one imaging mode can catch everything that's going on inside it. Over the years, multiple "brain maps" have emerged, each focusing on different brain processes, from metabolism to cognitive ...

Oncology & Cancer

Gene editing technique helps find cancer's weak spots

Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells. This concept is called "synthetic lethality" ...

Genetics

Linking gene expression and DNA methylation in single cells

A new method by researchers in the UK and Belgium makes it possible to study the epigenome and transcriptome of a single cell at the same time. The protocol, published in Nature Methods, helps scientists pinpoint the relationship ...

Neuroscience

A 'GPS' to navigate the brain's neuronal networks

In new research published today by Nature Methods, scientists from the Hebrew University of Jerusalem and Harvard University have announced a "Neuronal Positioning System" (NPS) that maps the circuitry of the brain, similar ...

Oncology & Cancer

Single-nucleus RNA sequencing, droplet by droplet

Last year Broad researchers described a single-nucleus RNA sequencing method called sNuc-Seq. This system enabled researchers to study the gene expression profiles of difficult-to-isolate cell types as well as cells from ...

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