Proceedings of the National Academy of Sciences

Parkinson's & Movement disorders

Novel test holds promise for detecting Parkinson's disease early

In the development of Parkinson's disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms. But without a test that can detect these changes, it's difficult ...

Radiology & Imaging

Targeted MRI detects chronic liver disease

Chronic liver diseases such as hepatitis, liver cirrhosis, and hepatocellular carcinoma are a major cause of morbidity and mortality worldwide. Fibrosis—the thickening and scarring of connective tissue—plays a major role ...

Oncology & Cancer

Scientists show reprogrammed fat cells support tumor growth

Mutations of the tumor suppressor p53 not only have a growth-promoting effect on the cancer cells themselves, but also influence the cells in the tumor's microenvironment. Scientists at the German Cancer Research Center (DKFZ) ...

Oncology & Cancer

Researchers uncover on/off switch for breast cancer metastasis

Despite their promise, immunotherapies fail to treat many cancers, including over 80% of some of the most advanced breast cancers. And many of those patients who do respond still experience metastases eventually. New research ...

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