AIDS vaccine trials may have added risk

March 21, 2008

Two field tests of an AIDS vaccine not only failed to protect people from the virus but may have put them at greater risk, U.S. researchers said.

The results of the worldwide trials prompted scientific inquiry as researchers try to assess what happened and whether they should known the outcome, The Washington Post reported Friday.

Both field tests were halted in September and seven other trials of similarly designed AIDS vaccines have been stopped or postponed indefinitely.

"This is on the same level of catastrophe as the (NASA space shuttle) Challenger disaster," said Robert Gallo, co-discoverer of the human immunodeficiency virus, the virus that causes AIDS, and head of the Institute for Human Virology in Baltimore.

The STEP and Phambili studies used the same vaccine and were stopped when it became evident the studies were futile and possibly harmful, the Post reported.

One hypothesis for what went wrong is the vaccine somehow prepared the immune system to be more susceptible to HIV infection, a scenario that wasn't foreseen or suggested by previous studies, the Post said.

The National Institutes of Health in Bethesda, Md, which funded the trials, will meet week to reassess its AIDS vaccine program.

Copyright 2008 by United Press International

Explore further: Fighting HIV on multiple fronts might lead to vaccine

Related Stories

Fighting HIV on multiple fronts might lead to vaccine

September 20, 2017
A combination antibody strategy could be the key to halting the spread of HIV, according to results from two promising animal studies.

Three-in-one antibody protects monkeys from HIV-like virus

September 20, 2017
A three-pronged antibody made in the laboratory protected monkeys from infection with two strains of SHIV, a monkey form of HIV, better than individual natural antibodies from which the engineered antibody is derived, researchers ...

Hurricane-battered Caribbean now faces health peril

September 7, 2017
Caribbean islands battered by Hurricane Irma now face a mighty task: preventing the rampant spread of disease as hospitals and clinics struggle to function and microbe-spreading mosquitoes and rats multiply.

Candidate AIDS vaccine passes early test

July 24, 2017
The three-decade-old quest for an AIDS vaccine received a shot of hope Monday when developers announced that a prototype triggered the immune system in an early phase of human trials.

Experimental HIV vaccine regimen is well-tolerated, elicits immune responses

July 24, 2017
Results from an early-stage clinical trial called APPROACH show that an investigational HIV vaccine regimen was well-tolerated and generated immune responses against HIV in healthy adults. The APPROACH findings, as well as ...

Paris spotlight on latest in AIDS science

July 21, 2017
Some 6,000 HIV experts gather in Paris from Sunday to report advances in AIDS science as fading hopes of finding a cure push research into new fields.

Recommended for you

HIV-AIDS: Following your gut

September 18, 2017
Researchers at the University of Montreal Hospital Research Centre (CRCHUM) have discovered a way to slow viral replication in the gastrointestinal tract of people infected by HIV-AIDS.

Study finds cutbacks in foreign aid for HIV treatment would cause great harm

August 30, 2017
Proposed reductions in U.S. foreign aid would have a devastating impact on HIV treatment and prevention programs in countries receiving such aid, an international team of investigators reports. In their paper published online ...

Cancer drug can reactivate HIV

August 24, 2017
People living with HIV must take a combination of three or more different drugs every day for the rest of their lives. Unfortunately, by following this strict treatment plan, they can suffer from side effects ranging from ...

New injectable antiretroviral treatment proved to be as effective as standard oral therapy

August 3, 2017
Intramuscularly administered antiretroviral therapy (ART) may be as effective for HIV treatment as current oral therapies. This is the main conclusion of a Phase II clinical trial carried out by 50 research centers around ...

Research finds home-based kit would increase HIV testing

July 31, 2017
Research led by William Robinson, PhD, Associate Research Professor of Behavioral & Community Health Sciences at LSU Health New Orleans School of Public Health, has found that 86% of heterosexuals who are at high risk for ...

Scientists divulge latest in HIV prevention

July 25, 2017
A far cry from the 1990s "ABC" campaign promoting abstinence and monogamy as HIV protection, scientists reported on new approaches Tuesday allowing people to have all the safe sex they want.

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

herpesdate
not rated yet Mar 21, 2008
good info. HIV People at www.HerpesFinder.com may like it

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.