Extracts from reishi mushroom and green tea shows synergistic effect to slow sarcoma

April 8, 2008

Both the reishi mushroom (Ganoderma lucidum; Lingzhi) and green tea have long held a place in traditional medicine in China and other Asian countries, for the general promotion of health and long life and for the treatment of specific diseases. More recent scientific studies have confirmed that both enhance the body¹s immune functions and hold the potential for treatment and prevention of many types of cancer.

Now a new study by Chinese scientists found that combining the active ingredients in the mushroom and the tea creates synergetic effects that inhibited the growth of tumors and delayed the time of death in mice with sarcomas.

Yan Zhang, of Pharmanex BJ Clinical Pharmacology Center in Beijing, reported the results of two studies at Experimental Biology 2008 in San Diego on Tuesday, April 8. The presentation was part of the scientific program of the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Reishi grows in damp, sunless mountain areas and was once a rare commodity. Today Reishi, like green tea polyphenols, is manufactured as an extract. Zhang and her colleagues examined products sold as ReishiMax and Tegreen, made by Utah-based Nu Skin Enterprises. ReishiMax contains high concentrations of the active components in the mushroom itself and cracked spores of the mushroom, including polysaccharides (13.5 percent) and triterpenes (6 percent), and Tegreen is almost completely (98-99 percent) made of tea polyphenols.

In the first study, designed to look at cancer treatment, mice were first injected intraperitoneally with sarcoma cells and then were given either low, medium or high dosages of ReishiMax or low, medium, or high dosages of a combination of ReishiMax and Tegree. A control group received neither product. All mice died of sarcoma development after treatment for 28 days. But treatment with the combination of reishi and green tea extracts delayed the animals¹ death within the first 12 days after sarcoma injection, compared to the animals receiving only ReishiMax.

In the second study, designed to look at cancer prevention, groups of healthy mice were given either low, medium or high dosages of ReishiMax or low, medium, or high dosages of a combination of ReishiMax and Tegreen. A control group received neither product.

After receiving the specified treatment for 14 days, mice were given a suspension of sarcoma cells subcutaneously, while the treatments were continued. On day 28, the sarcoma tumors under the skin were recovered from the mice and weighed. The tumor weight was reduced by 45 percent with the combination therapy, but in a much lesser degree with only the Reishi, compared to tumors in mice receiving no treatment, further confirming the synergy of the two together.

Source: Federation of American Societies for Experimental Biology

Explore further: Natural compound coupled with specific gut microbes may prevent severe flu

Related Stories

Natural compound coupled with specific gut microbes may prevent severe flu

August 3, 2017
Microbes that live in the gut don't just digest food. They also have far-reaching effects on the immune system. Now, a new study shows that a particular gut microbe can prevent severe flu infections in mice, likely by breaking ...

Research suggests that green tea, exercise boost weight loss, health

April 2, 2014
(Medical Xpress)—Mice on a high-fat diet that consumed decaffeinated green tea extract and exercised regularly experienced sharp reductions in final body weight and significant improvements in health, according to researchers ...

Drinking green tea before taking supplements may offer protection from toxicity

February 4, 2015
As high doses of green tea extract supplements for weight loss become more popular, potential liver toxicity becomes a concern. In the last decade, dozens of people have been diagnosed with the condition. However, drinking ...

Green tea extract and exercise hinder progress of Alzheimer's disease in mice

May 4, 2015
According to the National Institutes of Health (NIH), Alzheimer's disease (AD) may affect as many as 5.5 million Americans. Scientists currently are seeking treatments and therapies found in common foods that will help stave ...

Down's syndrome 'treated' with green tea: study

June 7, 2016
A chemical in green tea has been shown to improve cognitive ability in persons with Down's syndrome, scientists and doctors said Tuesday.

Coffee and tea may contribute to a healthy liver, researchers say

August 17, 2013
Surprise! Your morning cup of tea or coffee may be doing more than just perking you up before work.

Recommended for you

Synthetic hydrogels deliver cells to repair intestinal injuries

October 23, 2017
By combining engineered polymeric materials known as hydrogels with complex intestinal tissue known as organoids - made from human pluripotent stem cells - researchers have taken an important step toward creating a new technology ...

Study reveals connection between microbiome and autoimmune disorders

October 23, 2017
Many people associate the word "bacteria" with something dirty and disgusting. Dr. Pere Santamaria disagrees. Called the microbiome, the bacteria in our bodies have all kinds of positive effects on our health, Santamaria ...

Engineered protein treatment found to reduce obesity in mice, rats and primates

October 19, 2017
(Medical Xpress)—A team of researchers with pharmaceutical company Amgen Inc. report that an engineered version of a protein naturally found in the body caused test mice, rats and cynomolgus monkeys to lose weight. In their ...

New procedure enables cultivation of human brain sections in the petri dish

October 19, 2017
Researchers at the University of Tübingen have become the first to keep human brain tissue alive outside the body for several weeks. The researchers, headed by Dr. Niklas Schwarz, Dr. Henner Koch and Dr. Thomas Wuttke at ...

Cancer drug found to offer promising results in treating sepsis in test mice

October 19, 2017
(Medical Xpress)—A combined team of researchers from China and the U.S. has found that a drug commonly used to treat lung cancer in humans offers a degree of protection against sepsis in test mice. In their paper published ...

Tracing cell death pathway points to drug targets for brain damage, kidney injury, asthma

October 19, 2017
University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.