A rare case of collagenous colitis presenting as protein-losing enteropathy

November 3, 2008

Since the first report in 1976, collagenous colitis has been associated with a variety of conditions, including use of non-steroidal anti-inflammatory drugs and proton pump inhibitors. This condition is characterized by chronic watery diarrhea and abnormal deposition of collagen beneath the colonic epithelium. Severe hypoproteinemia due to enteric protein loss is rare unless accompanied by small bowel malabsorption syndrome. To the best of authors' knowledge, only 1 case of collagenous colitis associated with protein-losing enteropathy (PLE) in the absence of small bowel disease has been reported.

An article to be published on October 21, 2008 in the World Journal of Gastroenterology addresses this case. The research team led by Keiko Yamagami from Osaka City General Hospital of Japan reported herein another case of collagenous colitis associated with PLE without small bowel disease, in which PLE was diagnosed by 99mTc-human albumin scintigraphy.

They have reported the case of a patient with collagenous colitis who presented with PLE. Prednisolone treatment ameliorated diarrhea and hypoproteinemia.

Collagenous colitis should be included in the differential diagnosis of chronic diarrhea with hypoproteinemia to achieve appropriate management. Treatment with prednisolone may be effective for PLE associated with collagenous colitis.

Source: World Journal of Gastroenterology

Related Stories

Recommended for you

Decrease in sunshine, increase in Rickets

November 17, 2017
A University of Toronto student and professor have teamed up to discover that Britain's increasing cloudiness during the summer could be an important reason for the mysterious increase in Rickets among British children over ...

Anti-malaria drug shows promise as Zika virus treatment

November 17, 2017
A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective ...

Scientists identify biomarkers that indicate likelihood of survival in infected patients

November 17, 2017
Scientists have identified a set of biomarkers that indicate which patients infected with the Ebola virus are most at risk of dying from the disease.

Research team unlocks secrets of Ebola

November 16, 2017
In a comprehensive and complex molecular study of blood samples from Ebola patients in Sierra Leone, published today (Nov. 16, 2017) in Cell Host and Microbe, a scientific team led by the University of Wisconsin-Madison has ...

Study raises possibility of naturally acquired immunity against Zika virus

November 16, 2017
Birth defects in babies born infected with Zika virus remain a major health concern. Now, scientists suggest the possibility that some women in high-risk Zika regions may already be protected and not know it.

A structural clue to attacking malaria's 'Achilles heel'

November 16, 2017
Researchers from The Scripps Research Institute (TSRI) and PATH's Malaria Vaccine Initiative (MVI) have shed light on how the human immune system recognizes the malaria parasite though investigation of antibodies generated ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.