Link found between liver disease and falls in old age

February 26, 2010, Newcastle University

(PhysOrg.com) -- A study carried out at Newcastle University has discovered a link between liver disease and the rate of falls in elderly people.

The findings suggest that patients suffering from Primary Biliary Cirrhosis (PBC) are more than twice as likely to fall as non-sufferers and could lead to targeted treatment which would reduce physical and emotional pain, as well as save NHS money.

The research, which is published in the current edition of the Quarterly Journal of Medicine, looked at patients suffering from PBC. Of those, 72% had had at least one fall, significantly higher than the rate of falls in the control group. Fifty five per cent had suffered a fall in the past year and 22% were regular fallers, having had more than one fall in the previous year.

In each case this was more than double the rate for people who do not suffer from PBC. Every year the NHS spends £1b treating falls injuries, about £7.8m of that connected to PBC. This finding could potentially save a significant proportion of that cash, as well as the physical and emotional pain caused by falls.

Many of those who had fallen had suffered serious injuries, including , and one in five of the PBC fallers had to be admitted to hospital as a result of their fall, compared with none from the control group who had to be admitted.

PBC is a chronic condition which mainly affects women, with around 40,000 total sufferers in the UK. It often runs in families and is not caused by drinking too much alcohol.

The findings show that falls and resultant injury are prevalent in PBC and more common than previously recognized. It is believed abnormalities in blood pressure control, poor balance and are causing the falls, as well as poor memory and having a fear of falling (low confidence to go out etc).
Experts say that addressing postural dizziness, poor balance and lower limb weakness using a multi-disciplinary approach has the potential to reduce falls, injuries and deaths, and as a result improve quality of life.

Dr James Frith, clinical research associate at Newcastle Biomedicine, a partnership between Newcastle University and Newcastle NHS Foundation, who led the research said: “Falls cause serious injuries to thousands of people every year. Now we have found this link we may be able to offer treatments to patients who are high risk and hopefully stop some of these falls from happening in the first place. A fall can cause huge emotional issues as well as the physical problems. People lose their confidence and independence after they fall.

“It appears that people with PBC are falling as a result of abnormal regulation of their blood pressure. There is a strong link between PBC and blood pressure regulation. In addition falls also appear to be related to abnormal gait and balance, which is probably a result of abnormalities in the system which controls blood pressure.

“A recent piece of research suggested that that many older women would prefer to die than suffer a broken hip, which would leave them feeling vulnerable and stop them living their life.”

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hlahore
not rated yet Feb 27, 2010
Link is probably due to the reduced vitamin D processing by a diseased liver. It is will established that low level of vitamin D results in increased falls. www.vitamindwiki.com

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