Acellular dermal matrix and short bowel syndrome

April 28, 2010

Short bowel syndrome has puzzled surgeons for a long time and the curative effect are unsatisfactory. In recent years, acellular dermal matrix (ADM) has been used in many fields for tissue regeneration or scarless healing. A research group in China evaluated the efficacy of acellular dermal matrix for intestinal elongation in animal model. It seemed that ADM was not suited to using alone as a scaffold for the intestinal elongation.

Acellular dermal matrix (ADM) is a dermal biomaterial in which all of the cellular elements have been removed. The biologic properties of ADM, including its ability to support repopulation with fibroblasts, revascularization, new collagen deposition and eventual absorption and replacement with native tissue permit its use in tissue reconstruction. A few studies for intestinal elongation have been performed, but the results are uncertain.

The research, led by Professor Wang from Department of General Surgery of Beijing Chaoyang Hospital, will be published on April 28,2010 in . The study was designed to use both the home-made and commercial acellular dermal matrix materials to investigate the efficacy of acellular dermal matrix for intestinal elongation. Different species were transplanted with the allograft materials respectively. Severe adhesions were found between the graft and surrounding intestine. The grafts were completely absorbed within postoperative two or three months except one. Histological observation showed inflammation in the grafts with fibrinoid necroses, infiltration of a large amount of neutrophils and leukomonocytes, and the degree varied in different stage. The neointestine with well-formed structures wasn't observed in the study.

It is believed that the ADM can be used as a for tissue regeneration with the normal morphology of the mucosa, submucosa, muscle and serosa layers. But it is not always the truth. In this study, the grafts were almost completely absorbed in two or three months. Pus could be seen in the lumens of ADM and histological examination showed the inflammatory exudates of and pus cells. The authors presumed inadequate blood supply and the rapid absorption perhaps were the most likely reasons.

This study was well designed according to previous work, but it showed a different result. The authors gave some possible reasons, which were worthy of in-depth study. Perhaps ADM can be used for intestinal elongation, but this study showed that some reforms were necessary.

More information: Xu HM, Wang ZJ, Han JG, Ma HC, Zhao B, Zhao BC. Application of acellular dermal matrix for intestinal elongation in animal models. World J Gastroenterol 2010; 16(16): 2023-2027, www.wjgnet.com/1007-9327/full/v16/i16/2023.htm

Related Stories

Recommended for you

New insights into the world of trypanosomes

August 23, 2017
Single specimens of the vermicular pathogens causing sleeping sickness swim inside the gut of the tsetse fly between blood cells which the fly has ingested from an infected mammal. This is where they start their week-long ...

Survey of DNA fragments circulating in the blood suggests vast microbial diversity

August 23, 2017
A new survey of DNA fragments circulating in human blood suggests our bodies contain vastly more diverse microbes than anyone previously understood. What's more, the overwhelming majority of those microbes have never been ...

Study a breakthrough in understanding chronic pain in children

August 23, 2017
A University of Calgary psychologist who studies pediatric pain has made a breakthrough in understanding the cause of chronic pain in adolescents—by focusing on those recovering from major surgeries.

Scientists develop infection model for tickborne flaviviruses

August 22, 2017
National Institutes of Health (NIH) scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus. Powassan virus was implicated in the death of a ...

Zika virus stifles pregnant women's weakened immune system to harm baby, study finds

August 21, 2017
The Zika virus, linked to congenital birth defects and miscarriages, suppresses a pregnant woman's immune system, enabling the virus to spread and increasing the chances an unborn baby will be harmed, a Keck School of Medicine ...

Fatty liver can cause damage to other organs via crosstalk

August 21, 2017
Nonalcoholic fatty liver disease is increasingly common. Approximately every third adult in industrialized countries has a morbidly fatty liver. This not only increases the risk of chronic liver diseases such as liver cirrhosis ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.