Early signs of heart disease in preadolescent children with type 1 diabetes

February 14, 2011

Cardiovascular disease is the leading cause of death in patients with diabetes. Patients with type 1diabetes have a 200 percent to 400 percent greater chance of developing cardiovascular disease than those without diabetes. Medical College of Wisconsin researchers at Children's Hospital of Wisconsin discovered the early signs of cardiovascular disease are likely to manifest before the onset of puberty in many children with diabetes.

Those findings are published in the February 2, 2011 online version of Diabetes Care and will be in the March 2011 issue of .

Led by Dr. Ramin Alemzadeh, professor of pediatrics at the college and pediatric endocrinologist at Children's Hospital of Wisconsin, and Senior Clinician Scientist at Children's Hospital's Max McGee Juvenile Diabetes Research Center, the researchers studied 21 preadolescent children (avg. age 8.5 years) with , and compared that group to 15 healthy siblings. Investigators looked at flow-mediated dilatation (FMD), a gauge of the health of a major blood vessel of the upper arm artery, in both groups. FMD percentage (FMD%,) is a way to measure any stiffening of the blood vessels; stiffening blood vessels is an early precursor of cardiovascular disease.

Children who had , family history of or premature from other causes were excluded. Blood samples were collected from all participants to monitor cholesterol and sugar levels.

When tested, the blood vessels of children with type 1 diabetes had a lower FMD% change, which means their blood vessels were less expandable than the control group suggesting that higher circulating glucose results in increased rigidity of blood vessels independent of serum cholesterol levels. The patients with diabetes also had vascular inflammation, which is a known harbinger of future cardiovascular risk. Long-term studies are needed to evaluate the progression of those vascular changes through puberty and beyond.

More information: The published paper, "Impaired Endothelial Function in Preadolescent Children with Type 1 Diabetes," was co-authored by Dr. Ghufran S. Babar, M.D., et al.

Related Stories

Recommended for you

Pair of discoveries illuminate new paths to flu and anthrax treatments

October 17, 2017
Two recent studies led by biologists at the University of California San Diego have set the research groundwork for new avenues to treat influenza and anthrax poisoning.

Portable 3-D scanner assesses patients with elephantiasis

October 17, 2017
An estimated 120 million people worldwide are infected with lymphatic filariasis, a parasitic, mosquito-borne disease that can cause major swelling and deformity of the legs, a condition known as elephantiasis. Health-care ...

New tools to combat kidney fibrosis

October 16, 2017
Interstitial fibrosis – excessive tissue scarring – contributes to chronic kidney disease, which is increasing in prevalence in the United States.

How hepatitis C hides in the body

October 13, 2017
The Hepatitis C (HCV) virus is a sly enemy to have in one's body. Not only does it manage to make itself invisible to the immune system by breaking down communication between the immune cells, it also builds secret virus ...

Largest study yet of malaria in Africa shows historical rates of infection

October 12, 2017
(Medical Xpress)—A team of researchers with members from the Kenya Medical Research Institute, the University of Oxford and the University of KwaZulu-Natal has conducted the largest-ever study of the history of malaria ...

Promising new target for treatment of psoriasis is safe, study shows

October 11, 2017
A protein known to play a significant role in the development of psoriasis can be prevented from functioning without posing a risk to patients, scientists at King's College London have found.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.