Honey can reverse antibiotic resistance

April 13, 2011, Society for General Microbiology

Manuka honey could be an efficient way to clear chronically infected wounds and could even help reverse bacterial resistance to antibiotics, according to research presented at the Society for General Microbiology's Spring Conference in Harrogate.

Professor Rose Cooper from the University of Wales Institute Cardiff is looking at how manuka honey interacts with three types of bacteria that commonly infest wounds: Pseudomonas aeruginosa, Group A Streptococci and Meticillin-resistant Staphylococcus aureus (MRSA). Her group has found that honey can interfere with the growth of these bacteria in a variety of ways and suggests that honey is an attractive option for the treatment of drug-resistant wound infections.

Honey has long been acknowledged for its antimicrobial properties. Traditional remedies containing honey were used in the topical treatment of wounds by diverse ancient civilisations. Manuka honey is derived from nectar collected by honey bees foraging on the manuka tree in New Zealand and is included in modern licensed wound-care products around the world. However, the antimicrobial properties of honey have not been fully exploited by modern medicine as its mechanisms of action are not yet known.

Professor Cooper's group is helping to solve this problem by investigating at a molecular level the ways in which manuka honey inhibits wound-infecting bacteria. "Our findings with streptococci and pseudomonads suggest that manuka honey can hamper the attachment of bacteria to tissues which is an essential step in the initiation of acute infections. Inhibiting attachment also blocks the formation of biofilms, which can protect bacteria from antibiotics and allow them to cause persistent infections," explained Professor Cooper. "Other work in our lab has shown that honey can make MRSA more sensitive to antibiotics such as oxacillin - effectively reversing . This indicates that existing antibiotics may be more effective against drug-resistant infections if used in combination with manuka honey."

This research may increase the clinical use of manuka honey as doctors are faced with the threat of diminishingly effective antimicrobial options. "We need innovative and effective ways of controlling wound infections that are unlikely to contribute to increased antimicrobial resistance. We have already demonstrated that manuka is not likely to select for honey-resistant bacteria," said Professor Cooper. At present, most antimicrobial interventions for patients are with systemic antibiotics. "The use of a topical agent to eradicate bacteria from wounds is potentially cheaper and may well improve antibiotic therapy in the future. This will help reduce the transmission of antibiotic-resistant from colonised wounds to susceptible patients."

Related Stories

Recommended for you

Iron triggers dangerous infection in lung transplant patients, study finds

February 21, 2018
Researchers at the Stanford University School of Medicine have identified elevated tissue iron as a risk factor for life-threatening fungal infections in lung transplant recipients.

Neuroimaging reveals lasting brain deficits in iron-deficient piglets

February 21, 2018
Iron deficiency in the first four weeks of a piglet's life - equivalent to roughly four months in a human infant - impairs the development of key brain structures, scientists report. The abnormalities remain even after weeks ...

Products derived from plants offer potential as dual-targeting agents for experimental cerebral malaria

February 21, 2018
Malaria, a life-threatening disease usually caused when parasites from the Plasmodium family enter the bloodstream of a person bitten by a parasite-carrying mosquito, is a severe health threat globally, with 200 to 300 million ...

Scientists in Germany improve malaria drug production

February 21, 2018
Scientists in Germany who developed a new way to make a key malaria drug several years ago said Wednesday they have come up with a technique to make the process even more efficient, which should increase global access and ...

Early results from clinical trials not all they're cracked up to be, shows new research

February 21, 2018
When people are suffering from a chronic medical condition, they may place their hope on treatments in clinical trials that show early positive results. However, these results may be grossly exaggerated in more than 1 in ...

Clues to obesity's roots found in brain's quality control process

February 20, 2018
Deep in the middle of our heads lies a tiny nub of nerve cells that play a key role in how hungry we feel, how much we eat, and how much weight we gain.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.