New lung cancer staging system (TNM 7) better predicts local/regional recurrence, study shows

April 1, 2011, International Association for the Study of Lung Cancer

The new TNM 7 lung cancer staging system seems to be a better predictor of local or regional recurrence of lung cancer following surgery, according to a study published in the April issue of the Journal of Thoracic Oncology.

Being able to better define which patients might experience a is important, especially given the controversies surrounding the use of adjuvant therapies, particularly postoperative (RT), for patients with non-small cell lung cancer (NSCLC).

In 2009, the International Association for the Study of Lung Cancer (IASLC) published its 7th edition of the tumor, node, metastasis (TNM) classification, which was developed in collaboration with the American Joint Committee on Cancer and the Union Internationale Contre le Cancer. The changes were based on an analysis of a large international database.

Researchers at Duke University School of Medicine in Durham, N.C., analyzed 709 patients who had undergone surgery for non-small cell between 1995 and 2005. Stage was assigned based on both TNM 6 and TNM 7. The 5-year actuarial risk of local/regional recurrence (LRR) for all patients was 23%. None of the patients received any or radiation therapy.

When patients were converted from TNM 6 to TNM 7, about 13% were placed in a higher stage and 8% in a lower stage. For most malignancies, increasing stage is generally associated with a higher risk of .

Five-year rates of local/regional recurrence for stages IA, IB, IIA, IIB and IIIA disease using TNM 6 were 16%, 26%, 43%, 35% and 40%, respectively. Using TNM 7, the corresponding rates were 16%, 23%, 37%, 39% and 30%.

"The TNM 7 system seems to be a better predictor for LRR after surgery for NSCLC than TNM 6," researchers wrote in the study. "This information may prove to be valuable when designing future studies of postoperative RT."

More information: journals.lww.com/jto/pages/default.aspx

Related Stories

Recommended for you

Scientists block the siren call of two aggressive cancers

January 23, 2018
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

Boosting cancer therapy with cross-dressed immune cells

January 22, 2018
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods.

Workouts may boost life span after breast cancer

January 22, 2018
(HealthDay)—Longer survival after breast cancer may be as simple as staying fit, new research shows.

Cancer patients who tell their life story find more peace, less depression

January 22, 2018
Fifteen years ago, University of Wisconsin–Madison researcher Meg Wise began interviewing cancer patients nearing the end of life about how they were living with their diagnosis. She was surprised to find that many asked ...

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.