Heart cells derived from stem cells used to study heart diseases

May 9, 2011

(PhysOrg.com) -- A research team at the University of Wisconsin School of Medicine and Public Health is the first to use heart cells derived from stem cells to specifically study certain genetic mechanisms of heart diseases.

Researchers led by Drs. Craig January and Tim Kamp, professors of medicine at the UW School of Medicine and Public Health, are using iPSC (induced-pluripotent stem cell) technology to make heart cells from .

The goal is to offer a cell model allowing researchers to study disease mechanisms, and new treatments and therapies for genetically based heart diseases such as inherited arrhythmias.

The UW group is among the first to use research of this kind specifically for certain genetically based heart diseases. Their results show that the study of heart cells derived from offer a powerful tool for understanding and treating genetically based .

Dr. January says, "By using patient-derived cardiomyocytes, or , to isolate a disease process outside of the body, we are able to gain information about how that gene affects the heart, and how it may respond to treatments and therapies, without having to greatly impact the affected patient. We can mimic the disease process in vitro, reproduce and observe the cells, and also test them with different medications to see how they will actually respond in the heart."

The full study will be presented by Dr. Sadguna Balijepalli, University of Wisconsin Cellular and Molecular Arrhythmia Research Program assistant scientist, at the Heart Rhythm Society's annual scientific sessions in San Francisco, on May 5 where the world's most renowned scientists and physicians present on a wide range of heart rhythm topics.

Related Stories

Recommended for you

Laser device placed on the heart identifies insufficient oxygenation better than other measures

September 20, 2017
A new device can assess in real time whether the body's tissues are receiving enough oxygen and, placed on the heart, can predict cardiac arrest in critically ill heart patients, report researchers at Boston Children's Hospital ...

Metabolism switch signals end for healing hearts

September 19, 2017
Researchers have identified the process that shuts down the human heart's ability to heal itself, and are now searching for a drug to reverse it.

Beta blockers not needed after heart attack if other medications taken

September 18, 2017
A new study from the University of North Carolina at Chapel Hill finds beta blockers are not needed after a heart attack if heart-attack survivors are taking ACE inhibitors and statins. The study is the first to challenge ...

Which single behavior best prevents high blood pressure?

September 15, 2017
(HealthDay)—You probably already know that certain healthy lifestyle behaviors can reduce your risk of developing high blood pressure, but is any one behavior more important than the others?

RESPECT trial shows closing a small hole in heart may protect against recurrent stroke

September 13, 2017
A device used to close a small hole in the heart may benefit certain stroke patients by providing an extra layer of protection for those facing years of ongoing stroke risk, according to the results of a large clinical trial ...

Study shows so-called 'healthy obesity' is harmful to cardiovascular health

September 11, 2017
Clinicians are being warned not to ignore the increased cardiovascular health risks of those who are classed as either 'healthy obese' or deemed to be 'normal weight' but have metabolic abnormalities such as diabetes.


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.