High blood pressure and pregnancy: Short- and long-term consequences

November 11, 2011

Two studies from the Mayo Clinic presented during the American Society of Nephrology's Annual Kidney Week provide new information related to high blood pressure during pregnancy.

In one study, Vesna Garovic, MD and her team examined the potential of a test done mid-pregnancy to predict which women will later develop , a late-pregnancy disorder that is characterized by high blood pressure and in the urine and that affects 3% to 5% of pregnancies. Left untreated, preeclampsia can lead to serious -- even fatal -- complications for a and her baby.

Among a group of 315 patients, 15 developed preeclampsia and 15 developed high blood pressure (but not preeclampsia) during pregnancy. All of the patients who developed preeclampsia tested positive in mid-pregnancy for a test that detects the shedding of certain called podocytes in the urine. None of those with only high blood pressure tested positive, and none of 44 women with normal pregnancies tested positive. Therefore, this test is highly accurate for predicting preeclampsia, which could alert clinicians to take steps to safeguard against the condition.

In another study, Dr. Garovic's team looked at the long-term health effects of high blood pressure during pregnancy. They identified female residents of Rochester, Minnesota and the surrounding townships in Olmsted County who delivered between 1976 and 1982. The investigators divided the women into two groups -- those with high blood pressure during pregnancy and those without -- and followed them after they reached 40 years of age to monitor their heart and kidney health.

A total of 6,051 mothers delivered between 1976 and1982, and 607 women had high blood pressure at the time while 5,444 did not. After the women reached age 40, women who had high blood pressure during pregnancy were much more likely to experience high blood pressure, , and strokes than women who did not have during pregnancy (51% vs 31%, 14% vs 10%, and 8% vs 4%, respectively).

"Studies of the associations of hypertensive pregnancy disorders with maternal risks for future cardiovascular disease could lead to new guidelines for screening and treatment of women at risk, with the ultimate goal of improving cardiovascular health in women," said Dr. Garovic.

Explore further: New findings may help explain high blood pressure in pregnancy

More information: Study authors for "Podocyturia Is an Early Marker That Distinguishes among Normotensive Pregnancy, Gestational Hypertension, and Preeclampsia" (abstract FR-OR292) include Steven Wagner, MD, Iasmina Craici, MD, Juan C. Calle, MD, Christina Wood-wentz, Kent R. Bailey, PhD, Stephen T. Turner, MD, Joseph P. Grande, MD, PhD and Vesna D. Garovic, MD.

Study authors for "Women with a History of Hypertensive Pregnancy Disorders Are at Increased Risk for Future Cardiovascular and Renal Disease: A Population-Based Cohort Study" (abstract TH-OR115) include Catherine M. Brown, MD, Slavica Katusic, Cynthia L. Leibson, Jeanine Ransom, Stephen T. Turner, MD, Veronique L. Roger and Vesna D. Garovic, MD.

Related Stories

New findings may help explain high blood pressure in pregnancy

October 31, 2011
Virginia Commonwealth University School of Medicine researchers have discovered that the infiltration of white blood cells into an expectant mother's blood vessels may explain high blood pressure in pregnancy.

Pre-Existing hypertension linked to depression in pregnant women

November 11, 2011
Women with a history of high blood pressure before getting pregnant have a higher risk of depression than women who develop pregnancy-related hypertension, according to a new study.

Recommended for you

Women exposed to smoke while in womb more likely to miscarry

July 13, 2017
Women exposed to cigarette smoke while in their mothers' wombs are more likely to experience miscarriage as adults, according to new research from the University of Aberdeen.

Lack of a hormone in pregnant mice linked to preeclampsia

June 30, 2017
(Medical Xpress)—A team of researchers from Singapore, the Netherlands and Turkey has isolated a hormone in pregnant mice that appears to be associated with preeclampsia—a pregnancy-related condition characterized by ...

Aspirin reduces risk of pre-eclampsia in pregnant women

June 28, 2017
Taking a low-dose aspirin before bed can reduce the risk of pre-eclampsia, which can cause premature birth and, in extreme cases, maternal and foetal death.

The biology of uterine fluid: How it informs the fetus of mom's world

June 22, 2017
A developing fetus bathes in a mixture of cellular secretions and proteins unique to its mother's uterus. Before fertilization, the pH of uterine fluid helps create a conducive environment for sperm migration, and afterward, ...

New clues in puzzle over pre-eclampsia and cholesterol regulation

June 21, 2017
Scientists studying a mystery link between the dangerous pregnancy complication pre-eclampsia and an increased risk of heart disease in later life for both mother and child have uncovered important new clues.

Are maternal hormones different when carrying a boy or a girl?

June 15, 2017
With advances in prenatal testing it's now possible to find out whether a pregnancy will result in a male or female baby as early as eight weeks' gestation.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.