Diseases, Conditions, Syndromes

Researchers close in on preeclampsia cure

Researchers from Western and Brown University have made groundbreaking progress towards identifying the root cause and potential therapy for preeclampsia.


How cell-free RNA could revolutionize preeclampsia diagnosis

Preeclampsia is a serious pregnancy disorder, marked by high blood pressure and the presence of proteins in urine, affecting between 2% and 4% of pregnant women worldwide, leading to about 46,000 maternal deaths and about ...


How preeclampsia accelerates aging in women

Preeclampsia—the life-threatening surge in blood pressure that strikes 1 in 25 pregnancies—is an enigmatic condition. Each year, it causes the deaths of more than 70,000 women worldwide. Because scientists do not know ...

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Pre-eclampsia or preeclampsia is a medical condition in which hypertension arises in pregnancy (pregnancy-induced hypertension) in association with significant amounts of protein in the urine.

Pre-eclampsia refers to a set of symptoms rather than any causative factor, and there are many different causes for the condition. It appears likely that there are substances from the placenta that can cause endothelial dysfunction in the maternal blood vessels of susceptible women. While blood pressure elevation is the most visible sign of the disease, it involves generalized damage to the maternal endothelium, kidneys, and liver, with the release of vasoconstrictive factors being secondary to the original damage.

Pre-eclampsia may develop from 20 weeks gestation (it is considered early onset before 32 weeks, which is associated with increased morbidity). Its progress differs among patients; most cases are diagnosed pre-term. Pre-eclampsia may also occur up to six weeks post-partum. Apart from Caesarean section or induction of labor (and therefore delivery of the placenta), there is no known cure. It is the most common of the dangerous pregnancy complications; it may affect both the mother and the unborn child.

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