Researchers identify environmental exposure to organochlorines may impact male reproduction

January 9, 2012, George Washington University Medical Center

Melissa Perry, Sc.D., M.H.S., professor and chair of the Department of Environmental and Occupational Health at the GW School of Public Health and Health Services and adjunct associate professor at the Harvard School of Public Health, led an observational study indicating that environmental exposure to organochlorine chemicals, including Polychlorinated Biphenyls (PCBs) and p,p'-DDE (the main metabolite of the insecticide DDT) can affect male reproduction. The research was published online on Dec. 21, 2011 in the journal Environmental Health Perspectives.

The researchers studied 192 men who were part of couples that were sub-fertile, to see if the men with higher levels of organochlorines in their blood showed evidence of increased rates of sperm abnormalities. They looked for sperm disomy, which occurs when have an abnormal number of chromosomes. While all men have a certain number of sperm with such abnormalities, researchers found that men with higher levels of DDE and PCBs had significantly higher rates of sperm abnormalities.

"This research adds to the already existing body of evidence suggesting that environmental exposure to certain chemicals can affect and reproduction. We need to further understand the mechanisms through which these chemicals impact sperm," said Dr. Perry. "While we cannot avoid chemicals that already persist in the environment, it is imperative that decisions about putting biologically active chemicals into the environment need to be made very carefully, because there can be unanticipated consequences down the road."

The researchers used a new sperm imaging methodology developed by Dr. Perry and colleagues to detect the chromosomal abnormalities, which allowed them to study a larger sampling of individuals than previous studies.

Explore further: Paternal exposures can adversely affect sperm

More information: To view the 'Ahead of Print' version of this research paper on the Environmental Health Perspectives Web site, visit: ehp03.niehs.nih.gov/article/fe … 0.1289%2Fehp.1104017

Related Stories

Paternal exposures can adversely affect sperm

June 20, 2011
Acording to the California Teratogen Information Service (CTIS) Pregnancy Health Information Line, more studies are needed to evaluate men and the potential effect of illnesses, medications and lifestyle habits on fertility ...

Recommended for you

Removing sweets from checkouts linked to dramatic fall in unhealthy snack purchases

December 18, 2018
Policies aimed at removing sweets and crisps from checkouts could lead to a dramatic reduction to the amount of unhealthy food purchased to eat 'on the go' and a significant reduction in that purchased to take home, suggests ...

Junk food diet raises depression risk, researchers find

December 18, 2018
A diet of fast food, cakes and processed meat increases your risk of depression, according to researchers at Manchester Metropolitan University.

Children of problem drinkers more likely to marry someone with a drinking problem: study

December 18, 2018
Children of parents who have alcohol use disorder are more likely to get married under the age of 25, less likely to get married later in life, and more likely to marry a person who has alcohol use disorder themselves, according ...

Folate deficiency creates hitherto unknown problems in connection with cell division

December 17, 2018
Folate deficiency creates more problems in connection with DNA replication than researchers had hitherto assumed, researchers from the University of Copenhagen show in a new study. Once a person lacks folate, the damage caused ...

A co-worker's rudeness can affect your sleep—and your partner's, study finds

December 14, 2018
Rudeness. Sarcastic comments. Demeaning language. Interrupting or talking over someone in a meeting. Workplace incivilities such as these are becoming increasingly common, and a new study from Portland State University and ...

Study shows magnesium optimizes vitamin D status

December 14, 2018
A randomized trial by Vanderbilt-Ingram Cancer Center researchers indicates that magnesium optimizes vitamin D status, raising it in people with deficient levels and lowering it in people with high levels.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.