Researchers identify environmental exposure to organochlorines may impact male reproduction

January 9, 2012

Melissa Perry, Sc.D., M.H.S., professor and chair of the Department of Environmental and Occupational Health at the GW School of Public Health and Health Services and adjunct associate professor at the Harvard School of Public Health, led an observational study indicating that environmental exposure to organochlorine chemicals, including Polychlorinated Biphenyls (PCBs) and p,p'-DDE (the main metabolite of the insecticide DDT) can affect male reproduction. The research was published online on Dec. 21, 2011 in the journal Environmental Health Perspectives.

The researchers studied 192 men who were part of couples that were sub-fertile, to see if the men with higher levels of organochlorines in their blood showed evidence of increased rates of sperm abnormalities. They looked for sperm disomy, which occurs when have an abnormal number of chromosomes. While all men have a certain number of sperm with such abnormalities, researchers found that men with higher levels of DDE and PCBs had significantly higher rates of sperm abnormalities.

"This research adds to the already existing body of evidence suggesting that environmental exposure to certain chemicals can affect and reproduction. We need to further understand the mechanisms through which these chemicals impact sperm," said Dr. Perry. "While we cannot avoid chemicals that already persist in the environment, it is imperative that decisions about putting biologically active chemicals into the environment need to be made very carefully, because there can be unanticipated consequences down the road."

The researchers used a new sperm imaging methodology developed by Dr. Perry and colleagues to detect the chromosomal abnormalities, which allowed them to study a larger sampling of individuals than previous studies.

Explore further: Paternal exposures can adversely affect sperm

More information: To view the 'Ahead of Print' version of this research paper on the Environmental Health Perspectives Web site, visit: ehp03.niehs.nih.gov/article/fe … 0.1289%2Fehp.1104017

Related Stories

Paternal exposures can adversely affect sperm

June 20, 2011
Acording to the California Teratogen Information Service (CTIS) Pregnancy Health Information Line, more studies are needed to evaluate men and the potential effect of illnesses, medications and lifestyle habits on fertility ...

Recommended for you

To combat teen smoking, health experts recommend R ratings for movies that depict tobacco use

July 21, 2017
Public health experts have an unusual suggestion for reducing teen smoking: Give just about any movie that depicts tobacco use an automatic R rating.

Opioids and obesity, not 'despair deaths,' raising mortality rates for white Americans

July 20, 2017
Drug-related deaths among middle-aged white men increased more than 25-fold between 1980 and 2014, with the bulk of that spike occurring since the mid-1990s when addictive prescription opioids became broadly available, according ...

Aging Americans enjoy longer life, better health when avoiding three risky behaviors

July 20, 2017
We've heard it before from our doctors and other health experts: Keep your weight down, don't smoke and cut back on the alcohol if you want to live longer.

Parents have critical role in preventing teen drinking

July 20, 2017
Fewer teenagers are drinking alcohol but more needs to be done to curb the drinking habits of Australian school students, based on the findings of the latest study by Adelaide researchers.

Fresh fish oil lowers diabetes risk in rat offspring

July 19, 2017
Fresh fish oil given to overweight pregnant rats prevented their offspring from developing a major diabetes risk factor, Auckland researchers have found.

High-dose vitamin D doesn't appear to reduce the winter sniffles for children

July 18, 2017
Giving children high doses of vitamin D doesn't appear to reduce the winter sniffles, a new study has found.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.