Secondhand smoke results in graft rejection

February 23, 2012

A new study published in the American Journal of Transplantation reveals that cigarette smoke exposure, in a cause-effect manner, results in graft rejection that would have been prevented by certain drug treatments.

Led by Zhenhua Dai, MD, PhD, of the University of Texas Health Science Center, researchers used mouse transplant models to investigate the impact of second hand smoke (SHS) on transplant survival and its mechanism of action.

Seven to eight mice per group were exposed to SHS and treated with or without immunoregulatory agents. They were exposed to SHS 4 weeks before they were transplanted with islets under the kidney capsule. SHS was terminated once islet allografts were rejected. Recipient mice were untreated or exposed to SHS. The analysis of was performed using log-rank tests.

Results showed that SHS indeed harms long-term allograft survival. SHS suppressed expression of an enzyme in the grafts produced by innate . SHS hindered long-term islet allograft survival induced by CD154 costimulatory blockade via suppressing IDO expression and activity, while overexpression of IDO by islets restored their long-term survival.

These findings for the first time revealed an immunological mechanism underlying allograft rejection precipitated by the exposure to .

"Many people are not aware of the gradual failure of transplanted organs or grafts that is caused by cigarette smoking, although they do know that smoking can cause cancer as well as respiratory diseases," Dai notes. "Our findings will definitely promote the public awareness of the smoking problem with transplanted patients, which in turn could save their lives by either quitting smoking or avoiding exposure to after transplantation."

Explore further: Study examines factors in pediatric kidney transplant rejection

Related Stories

Study examines factors in pediatric kidney transplant rejection

July 18, 2011
Avoiding HLA-DR mismatching appears to be beneficial in pediatric kidney transplant patients, however the likelihood of finding a matching donor must be considered against the wait time for a possible donation, according ...

Recommended for you

World's first child hand transplant a 'success'

July 19, 2017
The first child in the world to undergo a double hand transplant is now able to write, feed and dress himself, doctors said Tuesday, declaring the ground-breaking operation a success after 18 months.

Knee surgery—have we been doing it wrong?

July 18, 2017
A team of University at Buffalo medical doctors have published a study that challenges a surgical practice used for decades during arthroscopic knee surgery.

New tools help surgeons find liver tumors, not nick blood vessels

July 17, 2017
The liver is a particularly squishy, slippery organ, prone to shifting both deadly tumors and life-preserving blood vessels by inches between the time they're discovered on a CT scan and when the patient is lying on an operating ...

Researchers discover indicator of lung transplant rejection

July 13, 2017
Research by scientists at Dignity Health St. Joseph's Hospital and Medical Center's Norton Thoracic Institute was published in the July 12, 2017 issue of Science Translational Medicine titled "Zbtb7a induction in alveolar ...

New device could make closing surgical incisions a cinch

July 7, 2017
Like many surgeons, Dr. Jason Spector is often faced with the challenge of securely closing the abdominal wall without injuring the intestines. If the process goes awry, there can be serious consequences for patients, including ...

Success with first 20 patients undergoing minimally invasive pancreatic transplant surgery

June 29, 2017
Surgeons at Johns Hopkins Medicine report that their first series of a minimally invasive procedure to treat chronic pancreas disease, known as severe pancreatitis, resulted in shorter hospital stays, less need for opioids ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.