Will you have a heart attack? New test can possibly predict

March 21, 2012 By LAURAN NEERGAARD , AP Medical Writer,
This undated handout images provided by Science Traditional Medicine/Scripps Translational Science Institute, shows on the left normal, healthy circulating endothelial cells (CEC). On the right are CECs from heart attack patients which appear abnormally large, misshapen and with multiple nuclei. Too often, people pass a cardiac checkup only to collapse with a heart attack days later. Now scientists have found a clue that one day may help doctors determine if a heart attack is imminent, in hopes of preventing it. (AP Photo/Scripps Translational Science Institute)

Too often, people pass a cardiac checkup only to collapse with a heart attack days later. Now scientists have found a clue that one day may help doctors determine if a heart attack is imminent, in hopes of preventing it.

Most heart attacks happen when fatty deposits in an artery burst open, and a blood clot then forms to seal the break. If the clot is too big, it blocks off blood flow.

The problem: Today's best tests can't predict when that's about to happen.

"We don't have a way to get at whether an artery's going to crack, the precursor to a heart attack," said Dr. Eric Topol, director of California's Scripps Translational Science Institute.

Wednesday, Scripps researchers reported a new lead - by searching people's blood for cells that appear to flake off the lining of a severely diseased artery.

Topol's team measured high levels of those cells, deformed ones, floating in the blood of 50 people who'd just had a heart attack. The research is reported in the journal Science Translational Medicine.

Next, Topol said his team soon will begin needed studies to learn how early those cells might appear before a heart attack, and if spotting them could allow use of clot-preventing drugs to ward off damage. Some San Diego emergency rooms will study an experimental blood test with chest-pain sufferers whose standard exams found no evidence of a heart attack, he said.

Don't expect a test to predict heart attacks any time soon - a lot more research is needed, caution heart specialists not involved with the study. But they're intrigued.

"This study is pretty exciting," said Dr. Douglas Zipes of Indiana University and past president of the American College of Cardiology. It suggests those cells are harmed "not just in the minutes prior" to a heart attack, he said, "but probably hours, maybe even days" earlier.

"It's a neat, provocative first step," added Dr. William C. Little, cardiology chief at Wake Forest Baptist Medical Center. "But it is not a biomarker ready for prime time."

About 935,000 people in the U.S. have a heart attack every year, according to government figures. Doctors can tell who's at risk: People with high blood pressure and cholesterol, who smoke, have diabetes, are overweight or sedentary.

But there's no way to tell when a heart attack is imminent. Tests can spot that an artery is narrowing, or if a heart attack is under way or already has damaged the heart muscle. They can't tell if the plaque inside arteries is poised to rupture.

So it's not that uncommon for someone to suffer a heart attack shortly after passing a stress test or being told that their chest pain was nothing to worry about.

Wednesday's study, funded by the National Institutes of Health, investigated cells shed from the endothelium, or the lining of blood vessels, into the bloodstream. They're called "circulating endothelial cells."

First, Topol's team paired with Veridex LLC, a Johnson & Johnson unit that makes technology used to find cancer cells floating in blood. Could it find these cardiovascular cells, too?

The team took blood samples from 50 heart attack patients - before they had any artery-disturbing tests or treatments - and from 44 healthy volunteers. They counted lots of the endothelial cells floating in the heart attack victims' blood, and very little in the healthy people's blood.

The big surprise: The cells in the heart patients were grossly deformed. "Sick cells," is how Topol describes them.

The study couldn't tell when those abnormal cells first appeared - and that's key, said Wake Forest's Little. It's not clear how many heart attacks happen too suddenly for any warning period.

But Topol theorizes there are plaques that break apart gradually and may shed these cells for up to two weeks before the heart attack. He cites autopsy studies that found people's arteries healed several plaque ruptures before the final one that killed them.

Topol said Scripps and Veridex have filed for a patent for a blood test to detect the abnormal cells.

Explore further: Study shows new drug helps 'bridge' stent patients to cardiac surgery

shares

Related Stories

Study shows new drug helps 'bridge' stent patients to cardiac surgery

January 17, 2012
New findings from a research study led by physicians at Scripps Health reveal that the drug cangrelor has the unique properties of achieving very fast blood thinning effects when needed to protect from heart attacks, but ...

New hidden heart attack culprit identified in women

September 26, 2011
Researchers at the Cardiac & Vascular Institute at NYU Langone Medical Center have identified a hidden culprit in the battle against women's heart disease. Plaque disruption, a rupture or ulceration of cholesterol plaque ...

Researchers probe link between people with mental illness and increased levels of mortality

May 31, 2011
(Medical Xpress) -- New research from the University of Leicester raises concerns about higher than expected mortality following acute coronary events such as heart attack in those with significant mental ill health.

Recommended for you

A nanoparticle inhalant for treating heart disease

January 18, 2018
A team of researchers from Italy and Germany has developed a nanoparticle inhalant for treating people suffering from heart disease. In their paper published in the journal Science Translational Medicine, the group describes ...

Starting periods before age of 12 linked to heightened risk of heart disease and stroke

January 15, 2018
Starting periods early—before the age of 12—is linked to a heightened risk of heart disease and stroke in later life, suggests an analysis of data from the UK Biobank study, published online in the journal Heart.

'Decorated' stem cells could offer targeted heart repair

January 10, 2018
Although cardiac stem cell therapy is a promising treatment for heart attack patients, directing the cells to the site of an injury - and getting them to stay there - remains challenging. In a new pilot study using an animal ...

Two simple tests could help to pinpoint cause of stroke

January 10, 2018
Detecting the cause of the deadliest form of stroke could be improved by a simple blood test added alongside a routine brain scan, research suggests.

Exercise is good for the heart, high blood pressure is bad—researchers find out why

January 10, 2018
When the heart is put under stress during exercise, it is considered healthy. Yet stress due to high blood pressure is bad for the heart. Why? And is this always the case? Researchers of the German Centre for Cardiovascular ...

Heart-muscle patches made with human cells improve heart attack recovery

January 10, 2018
Large, human cardiac-muscle patches created in the lab have been tested, for the first time, on large animals in a heart attack model. This clinically relevant approach showed that the patches significantly improved recovery ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.