Study finds psoriasis treatment increases skin cancer risk

March 29, 2012
Study finds psoriasis treatment increases skin cancer risk
The long-term risk of squamous cell carcinoma is significantly increased for patients with severe psoriasis who receive more than 350 psoralen and ultraviolet A treatments compared with those who receive fewer than 50 treatments, according to research published in the April issue of the Journal of the American Academy of Dermatology.

(HealthDay) -- The long-term risk of squamous cell carcinoma (SCC) is significantly increased for patients with severe psoriasis who receive more than 350 psoralen and ultraviolet A (PUVA) treatments compared with those who receive fewer than 50 treatments, according to research published in the April issue of the Journal of the American Academy of Dermatology.

To investigate the association between PUVA exposure and SCC and (BCC) risk, Robert S. Stern, M.D., of Harvard Medical School in Boston, on behalf of the PUVA Follow-up Study, used data from 1,380 patients with severe psoriasis enrolled in a who were treated with PUVA.

The researchers found that, from 1975 to 2005, 25 percent of study participants developed 2,973 biopsy-proven SCCs and 24 percent developed 1,729 BCCs. The risk of developing one or more SCC in a year correlated strongly with the total number of PUVA treatments, after adjustment for confounders (350 to 450 versus <50 treatments, incidence rate ratio [IRR], 6.01). The risk was considerably higher when all tumors were included (IRR, 20.92). The risks for BCC were much lower (person counts IRR, 3.09; tumor counts IRR, 2.12).

"Exposure to more than 350 PUVA treatments greatly increases the risk of SCC," the authors write. "The risks of SCC in long-term PUVA-treated patients should be considered in determining the risk of this therapy relative to other treatments for severe psoriasis."

Explore further: Coffee consumption associated with decreased risk for basal cell carcinoma

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Coffee consumption associated with decreased risk for basal cell carcinoma

October 24, 2011
Caffeine could be related to an inverse association between basal cell carcinoma risk and consumption of coffee, a study found.

Dose-Response link between tanning bed use, skin cancer

February 28, 2012
(HealthDay) -- Use of tanning beds, especially in high school and college, is associated with an increased risk of skin cancer, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

Researchers find smoking is strongly associated with squamous cell carcinoma among women

December 8, 2011
Women who have non-melanoma skin cancers are more likely to have smoked cigarettes compared to women without skin cancer, said researchers at Moffitt Cancer Center in Tampa, Fla., who published study results in a recent issue ...

Vitamin D levels appear to be associated with risk of skin cancer, although relationship is complex

August 15, 2011
As an individual's level of vitamin D increases, the risk of nonmelanoma skin cancer (NMSC) seems to increase as well, although factors such as ultraviolet (UV) radiation exposure may complicate the relationship, according ...

IBD patients face increased skin cancer risk

November 21, 2011
Certain patients with inflammatory bowel disease (IBD) may have an increased risk of skin cancer, which is intensified by the use of immunosuppressant medications , according to two new studies in Gastroenterology, the official ...

Coffee, caffeine not linked to psoriasis in U.S. women

March 21, 2012
(HealthDay) -- Coffee and caffeine are not associated with psoriasis incidence after adjustment for smoking, according to a research letter published in the March issue of the Archives of Dermatology.

Recommended for you

Researchers discover a new target for 'triple-negative' breast cancer

November 20, 2017
So-called "triple-negative" breast cancer is a particularly aggressive and difficult-to-treat form. It accounts for only about 10 percent of breast cancer cases, but is responsible for about 25 percent of breast cancer fatalities.

Study reveals new mechanism used by cancer cells to disarm attacking immune cells

November 20, 2017
A new study by researchers at The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute (OSUCCC - James) identifies a substance released by pancreatic cancer cells that protects ...

Clinical trial suggests new cell therapy for relapsed leukemia patients

November 20, 2017
A significant proportion of children and young adults with treatment-resistant B-cell leukemia who participated in a small study achieved remission with the help of a new form of gene therapy, according to researchers at ...

Cell-weighing method could help doctors choose cancer drugs

November 20, 2017
Doctors have many drugs available to treat multiple myeloma, a type of blood cancer. However, there is no way to predict, by genetic markers or other means, how a patient will respond to a particular drug. This can lead to ...

Lung cancer triggers pulmonary hypertension

November 17, 2017
Shortness of breath and respiratory distress often increase the suffering of advanced-stage lung cancer patients. These symptoms can be triggered by pulmonary hypertension, as scientists at the Max Planck Institute for Heart ...

Researchers discover an Achilles heel in a lethal leukemia

November 16, 2017
Researchers have discovered how a linkage between two proteins in acute myeloid leukemia enables cancer cells to resist chemotherapy and showed that disrupting the linkage could render the cells vulnerable to treatment. St. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.