Hematologic malignancies rapidly increasing and unaddressed in Sub-Saharan Africa
![The cancer clinic at UNC Project in Lilongwe, Malawi. Hematologic malignancies rapidly increasing and unaddressed in sub-Saharan Africa](https://scx1.b-cdn.net/csz/news/800a/2012/hematologicm.jpeg)
(Medical Xpress) -- Sub-Saharan Africa is experiencing a growing cancer burden, and hematologic malignancies account for almost 10 percent of cancer deaths in the region. In the United States and other resource-rich settings, patients with diseases such as non-Hodgkin lymphoma, Hodgkin lymphoma, leukemia and multiple myeloma have benefited from treatment advances that have resulted in unprecedented rates of long-term control.
A study
pre-published on-line in the March 28, 2012 issue of the journal Blood, argues that these diseases can be effectively treated in a resource-limited setting and offers a clinical service and research agenda to address the growing impact of hematologic malignancies in sub-Saharan Africa. UNC hematology/oncology and infectious disease fellow Satish Gopal, MD, MPH, is corresponding author on the study. He notes, “Aging, social and behavioral trends, HIV, and other endemic infections are all contributing to a rapidly increasing cancer burden in sub-Saharan Africa which has the potential to overwhelm fragmented and under-resourced health systems in this part of the world.”
Other challenges in the care of these patients include a high endemic infectious burden, as many antibacterial and antifungal drugs commonly used in developed regions are simply unavailable to support patients who are immunosuppressed from cancer treatment, HIV, malnutrition, and other factors. The region also lacks a blood transfusion infrastructure including lack of centralized national systems for blood collection and banking. Finally, pain management drugs are often highly-regulated or unavailable.
The research team suggests that strategies can be developed for addressing these issues, including development of conventional and new diagnostics adapted to low-resource settings, making cancer medicines affordable and integrating newer treatments, using the care and research infrastructure established to deal with HIV and other infectious diseases to study and control cancer, increasing global funding for cancer while rigorously assessing cost-effectiveness of cancer control measures, and addressing critical health worker shortages by focusing on training efforts.