New radiation therapy reduces treatment of gynecologic cancers from 5 weeks to 3 days

April 17, 2012, The Journal of Visualized Experiments
Stereotactic body radiation therapy may involve many individual radiation beams (blue vectors) all converging on single or multiple closely associated clinical radiation targets. Credit: © Journal of Visualized Experiments

About 71,500 women in the United States are diagnosed with a gynecologic cancer every year, according to the Centers for Disease Control. Researchers from University Hospitals Case Medical Center have developed a more effective way to treat gynecologic cancers, shortening radiation treatment time from five weeks to three days. The method will be published in the Journal of Visualized Experiments (JoVE) on April 17.

The new method, stereotactic body radiotherapy (SBRT) has been used on other , but Case Medical Center is the first treatment facility to apply it to . Dr. Charles Kunos, who co-authored the article, said the radiation therapy machine "looks like a robot you would make cars with, and targets specific ."

131 beams were used to treat on a pelvic relapse of a chemorefractory ovarian cancer target over 42 minutes. Credit: © Journal of Visualized Experiments

Unlike traditional radiation therapy, SBRT uses focused radiation beams and targets well-defined tumors. In order to focus in on the region, the tumors need to be imaged and marked (using fiduciary markers) in advance. During treatment with the Cyberknife system from Accuray, patients need to be immobilized, and even the movement from the patient's breathing needs to be taken into account.

The highly specific nature of the procedure not only shortens treatment time, it limits the effect of the radiation on healthy tissues.

"SBRT holds great promise for treating persistent or recurrent gynecologic cancers," said JoVE Science Editor, Dr. Nandita Singh. "SBRT can deliver radiation with high precision and is particularly effective in delivering reduced radiation to cancer targets that are refractory to chemotherapy and conventional radiation."

Dr. Kunos said he chose to publish the method in JoVE, the only peer reviewed, PubMed-indexed academic journal to publish all of its content in both text and video format, because he felt it was critical that he and his team have a high-quality video of the protocol for people to see when he and his team launch a nationwide clinical trial.

Explore further: Stereotactic radiotherapy provides excellent local control for lung malignancies

More information: To see the full video article, please click here: www.jove.com/details.php?id=3793&access=bs3ynror

Related Stories

Stereotactic radiotherapy provides excellent local control for lung malignancies

March 20, 2012
(Medical Xpress) -- Image-guided stereotactic radiation therapy is well tolerated and very effective in locally-controlling lung cancer, Methodist Cancer Center researchers report in the April issue of the Journal of Radiation ...

SBRT provides better outcomes than surgery for cancer patients with common lung disease

February 16, 2012
Stereotactic body radiotherapy (SBRT) provides better overall survival rates than surgery for lung cancer patients with severe chronic obstructive pulmonary disease (COPD), a disease commonly associated with lung cancer, ...

Recommended for you

Single blood test screens for eight cancer types

January 18, 2018
Johns Hopkins Kimmel Cancer Center researchers developed a single blood test that screens for eight common cancer types and helps identify the location of the cancer.

Researchers find a way to 'starve' cancer

January 18, 2018
Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital ...

How cancer metastasis happens: Researchers reveal a key mechanism

January 18, 2018
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial ...

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

January 18, 2018
Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists from the German Cancer Research ...

These foods may up your odds for colon cancer

January 18, 2018
(HealthDay)—Chowing down on red meat, white bread and sugar-laden drinks might increase your long-term risk of colon cancer, a new study suggests.

The pill lowers ovarian cancer risk, even for smokers

January 18, 2018
(HealthDay)—It's known that use of the birth control pill is tied to lower odds for ovarian cancer, but new research shows the benefit extends to smokers or women who are obese.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.