Family history of Alzheimer's affects functional connectivity

May 26, 2012
Family history of alzheimer's affects functional connectivity

(HealthDay) -- Cognitively normal individuals with a family history of late-onset Alzheimer's disease (AD) may display lower resting state functional connectivity in the default mode network (DMN) of the brain, and this effect is detectable even in those who do not carry the apolipoprotein E (APOE) ε4 allele, according to a study published online May 9 in the Annals of Neurology.

Liang Wang, M.D., of Washington University in St. Louis, and colleagues conducted a cohort study of 348 cognitively normal participants with or without a family history of late-onset AD to examine the effect of family history on the integrity of the DMN, and whether this effect is detectable in APOE ε4 noncarriers. Resting state functional connectivity magnetic resonance imaging was used to assess the integrity of the DMN.

The researchers found that patients with a family history of late-onset AD displayed reduced between nodes of the DMN, specifically the posterior cingulate cortex and medial temporal cortex. This was not attributable to structural atrophy in the medial temporal lobe. This effect was also seen in noncarriers of the APOE ε4 allele.

"Unknown genetic factors, embodied in a of late-onset AD, may affect DMN integrity prior to cognitive impairment," the authors conclude.

Several authors disclosed financial ties to the pharmaceutical industry related to the study of dementia treatments.

Explore further: Active lifestyle associated with less Alzheimer disease-related brain change among persons with APOE epsilon4 genotype

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Active lifestyle associated with less Alzheimer disease-related brain change among persons with APOE epsilon4 genotype

January 16, 2012
A sedentary lifestyle is associated with greater cerebral amyloid deposition, which is characteristic of Alzheimer’s disease (AD), among cognitively normal individuals with the ε4 allele of the apolipoprotein E ...

Activity in brain networks related to features of depression

April 3, 2012
Depressed individuals with a tendency to ruminate on negative thoughts, i.e. to repeatedly think about particular negative thoughts or memories, show different patterns of brain network activation compared to healthy individuals, ...

Recommended for you

Researchers describe new biology of Alzheimer's disease

November 20, 2017
In a new study, researchers from Boston University School of Medicine (BUSM) describe a unique model for the biology of Alzheimer's disease (AD) which may lead to an entirely novel approach for treating the disease. The findings ...

Study shows video games could cut dementia risk in seniors

November 16, 2017
Could playing video games help keep the brain agile as we age?

New player in Alzheimer's disease pathogenesis identified

November 14, 2017
Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check. The study, published in Nature Communications, ...

Biomarker may predict early Alzheimer's disease

November 10, 2017
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a peptide that could lead to the early detection of Alzheimer's disease (AD). The discovery, published in Nature Communications, may ...

Smell test challenge suggests clinical benefit for some before development of Alzheimer's

November 10, 2017
Researchers at Columbia University Medical Center (CUMC) and the New York State Psychiatric Institute (NYSPI) may have discovered a way to use a patient's sense of smell to treat Alzheimer's disease before it ever develops. ...

How SORLA protects against Alzheimer's disease

November 7, 2017
Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a new protective function for a brain protein genetically linked to Alzheimer's. The findings, published in the Journal of Experimental ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.