Gender, high DAS28-P index predictive of pain in early RA

May 18, 2012
Gender, high DAS28-P index predictive of pain in early RA

(HealthDay) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness and visual analog score) (DAS28-P) at baseline are predictive of less improvement in pain at one year, according to a study published online May 3 in Arthritis Care & Research.

Daniel F. McWilliams, Ph.D., of the University of Nottingham in the United Kingdom, and colleagues assessed the change in at one year using data from the Early Network database cohort of 1,189 individuals who completed the Short-Form-36 questionnaire bodily pain scores. Predictors of improvement in pain were investigated and the DAS28-P was measured at baseline.

At baseline, the researchers found that greater pain was associated with gender, poor mental health, smoking status, and high DAS28. The majority of patients continued to report bodily pain after one year. For patients whose disease remained active, the DAS28-P index did not change significantly. Significant predictors of less improvement in pain were female gender (adjusted odds ratio [aOR], 3.41) and high DAS28-P at baseline (aOR for tertiles, 2.09). Pain changes were not predicted by other conventional RA risk factors.

"The factors most likely to be related to poorer pain outcomes in early RA are female gender and a high baseline DAS28-P index," the authors write. "A high DAS28-P index may reflect greater contributions of non-inflammatory factors, such as central sensitization, to pain. Strategies in addition to inflammatory disease suppression may be required to adequately treat pain."

Two of the authors disclosed financial ties to Pfizer, which funded the data analysis for this study.

Explore further: Studies show siginificant benefits of yoga in 2 conditions

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Studies show siginificant benefits of yoga in 2 conditions

May 26, 2011
Individuals with rheumatoid arthritis who practice yoga showed statistically significant improvements in disease activity, according to a small study presented today at the EULAR 2011 Annual Congress.

Recommended for you

Osteoarthritis could be treated as two diseases, scientists reveal

January 10, 2018
Scientists at The University of Manchester have discovered that most people with osteoarthritis can be subdivided into two distinct disease groups, with implications for diagnosis and drug development.

US arthritis prevalence is much higher than current estimates

November 27, 2017
New research indicates that the prevalence of arthritis in the United States has been substantially underestimated, especially among adults

Maintaining sufficient vitamin D levels may help to prevent rheumatoid arthritis

November 20, 2017
Maintaining sufficient vitamin D levels may help to prevent the onset of inflammatory diseases like rheumatoid arthritis, research led by the University of Birmingham has discovered.

Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy

November 16, 2017
In the quest for a new and more effective treatment for rheumatoid arthritis, researchers from the Keck School of Medicine of USC looked to a primate that mostly roams the land in Asia, the Middle East and Africa. It was ...

Study lists foods for fighting rheumatoid arthritis symptoms and progression

November 8, 2017
A list of food items with proven beneficial effects on the progression and symptoms of rheumatoid arthritis is provided in a new study published today in Frontiers in Nutrition. The authors suggest incorporating these foods ...

Prototype equipment can detect rheumatoid arthritis

September 28, 2017
According to a first clinical study published in the scientific journal Photoacoustics, the University of Twente and various European partners have designed a device that shows the difference between healthy fingers and arthritic ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.