Fluticasone improves histologic eosinophilia in esophagitis

June 29, 2012
Fluticasone improves histologic eosinophilia in esophagitis
Swallowing aerosolized fluticasone improves histologic eosinophilia but does not improve dysphagia symptoms in adults with eosinophilic esophagitis, according to a study published online in the July issue of Clinical Gastroenterology and Hepatology.

(HealthDay) -- Swallowing aerosolized fluticasone improves histologic eosinophilia but does not improve dysphagia symptoms in adults with eosinophilic esophagitis (EoE), according to a study published online in the July issue of Clinical Gastroenterology and Hepatology.

To determine whether aerosolized fluticasone therapy improved symptomatic and histologic eosinophilia, Jeffrey A. Alexander, M.D., of the Mayo Clinic College of Medicine in Rochester, Minn., and colleagues conducted a randomized, double-blind, placebo-controlled trial involving adults (mean age, 37.5 years) with a new diagnosis of EoE. For six weeks, patients either swallowed 880 µg of aerosolized fluticasone (21 participants) or used a placebo inhaler twice daily (15 participants).

The researchers found that 62 percent of fluticasone-treated patients showed a complete histologic response, defined as a >90 percent reduction in mean eosinophil count, compared with none in the placebo group, in intention-to-treat analysis. In per-protocol analysis, 68 versus 0 percent had a histologic response. Eighty-one versus 8 percent of fluticasone- versus placebo-treated patients exhibited reduced eosinophil-derived neurotoxin staining. Dysphagia was reduced in 57 and 33 percent of patients treated with fluticasone and placebo, respectively (P = 0.22), in intention-to-treat analysis, and in 63 and 47 percent, respectively (P = 0.49), in per-protocol analysis. Esophageal candidiasis developed in 26 percent of fluticasone-treated patients and no patients in the group.

"In summary, this double-blind, placebo-controlled six-week trial of aerosolized fluticasone in the treatment of EoE found the treatment efficacious at decreasing esophageal eosinophilia and eosinophil activity," the authors write. "This histologic response, however, was not accompanied by a relief of symptomatic dysphagia."

One author disclosed financial ties to Meritage Pharmacia.

Abstract

Full Text

Editorial

Explore further: Elimination diet can treat eosinophilic esophagitis in adults

Related Stories

Elimination diet can treat eosinophilic esophagitis in adults

June 8, 2012
(HealthDay) -- A six-food elimination diet can successfully treat adults with eosinophilic esophagitis (EoE), according to a study published in the June issue of Gastroenterology.

Food elimination diet identifies causes of difficulty swallowing and swelling of the throat

June 20, 2012
A six-food elimination diet significantly improves symptoms in adult patients with eosinophilic esophagitis (EoE), according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. ...

Vitamin E or metformin may not be effective for treating liver disease in children and teens

April 26, 2011
In contrast to previous preliminary data, use of vitamin E or the diabetes drug metformin was not superior to placebo on a measured outcome for treating nonalcoholic fatty liver disease in children and adolescents, according ...

Recommended for you

Novel therapies for multidrug-resistant bacteria

October 23, 2017
During this innovative study published in PLOS One, researchers found that novel classes of compounds, such as metal-complexes, can be used as alternatives to or to supplement traditional antibiotics, which have become ineffective ...

Key discoveries offer significant hope of reversing antibiotic resistance

October 23, 2017
Resistance to antibiotics is becoming increasingly prevalent and threatens to undermine healthcare systems across the globe. Antibiotics including penicillins, cephalosporins and carbapenems are known as β-lactams and are ...

Pneumonia vaccine under development provides 'most comprehensive coverage' to date, alleviates antimicrobial concerns

October 20, 2017
In 2004, pneumonia killed more than 2 million children worldwide, according to the World Health Organization. By 2015, the number was less than 1 million.

Newly discovered viral marker could help predict flu severity in infected patients

October 20, 2017
Flu viruses contain defective genetic material that may activate the immune system in infected patients, and new research published in PLOS Pathogens suggests that lower levels of these molecules could increase flu severity.

Migraines may be the brain's way of dealing with oxidative stress

October 19, 2017
A new perspective article highlights a compelling theory about migraine attacks: that they are an integrated mechanism by which the brain protects and repairs itself. Recent insightful findings and potential ways to use them ...

H7N9 influenza is both lethal and transmissible in animal model for flu

October 19, 2017
In 2013, an influenza virus that had never before been detected began circulating among poultry in China. It caused several waves of human infection and in late 2016, the number of people to become sick from the H7N9 virus ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.